CAJ | 학술논문

沉默交配型信息调节因子2同源蛋白3（SIRT3）是Sirtuins脱乙酰基酶家族中的一员，是酵母沉默信息调节因子2的同源物，是一种依赖于烟酰胺腺嘌呤二核苷酸的Ⅲ类去乙酰化酶，它调节许多线粒体的蛋白质，这些蛋白质的功能关系到代谢、氧化应激及细胞存活。 SIRT3是线粒体适应性反应的调节因子，调节线粒体对应激等的适应性反应，包括代谢程序重排、加强抗氧化剂的防御机制等。另外，调控SIRT3可能是治疗线粒体功能障碍疾病的一个有希望的靶点。
침묵교배형신식조절인자2동원단백3（SIRT3）시Sirtuins탈을선기매가족중적일원，시효모침묵신식조절인자2적동원물，시일충의뢰우연선알선표령이핵감산적Ⅲ류거을선화매，타조절허다선립체적단백질，저사단백질적공능관계도대사、양화응격급세포존활。 SIRT3시선립체괄응성반응적조절인자，조절선립체대응격등적괄응성반응，포괄대사정서중배、가강항양화제적방어궤제등。령외，조공SIRT3가능시치료선립체공능장애질병적일개유희망적파점。
Silent mating type information regulation 2 homolog 3(SIRT3) is a member of Sirtuins family and is also homologue of silence information regulator 2.SIRT3 is a kind of NAD +-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism , oxidative stress,and cell survival.It is emerging as an instrumental regulator of the mitochondrial adaptive responses to stress ,in-cluding metabolic reprogramming and enhancing antioxidant defense mechanisms .Mitochondrial dysfunction is a key contributing factor in many diseases .The manipulation of SIRT3 could be a promising target for some diseases therapies.