CAJ | 학술논문

脓毒症是一个高发病率、高病死率的疾病。其发病特点是全身炎性反应失调引起的免疫功能障碍，因此如何选择最佳动物模型对研究脓毒症至关重要。盲肠结扎穿孔模型（ CLP）是目前研究脓毒症应用最广泛、最具代表意义的一种模型，更类似于人类脓毒症的进展和特点。尽管 CLP 不能完全复制临床的脓毒症，但其仍为脓毒症发病机制和防治研究提供了大量有意义的基础数据。该文对盲肠结扎穿孔术模型的研究应用予以综述，以促进实验研究与临床试验间的转化。
농독증시일개고발병솔、고병사솔적질병。기발병특점시전신염성반응실조인기적면역공능장애，인차여하선택최가동물모형대연구농독증지관중요。맹장결찰천공모형（ CLP）시목전연구농독증응용최엄범、최구대표의의적일충모형，경유사우인류농독증적진전화특점。진관 CLP 불능완전복제림상적농독증，단기잉위농독증발병궤제화방치연구제공료대량유의의적기출수거。해문대맹장결찰천공술모형적연구응용여이종술，이촉진실험연구여림상시험간적전화。
Sepsis is a high incidence and high mortality of the disease ,which is characterized by dysreg-ulated systemic in ammatory responses followed by immunosuppression , so how to choose the best animal model for the study of sepsis is crucial.Sepsis induced by cecal ligation and puncture ( CLP) is the most widely used model.Although CLP does not completely reproduce the complexity of human sepsis,the CLP model is one of the best representations of human sepsis which has made important contributions to our knowledge of the in ammation involved in sepsis and to the identi cation of therapeutic strategies .In this pa-per we gathered these datas on the cecal ligation and puncture-induced sepsis model for a review to narrow the gap between experimental sepsis models and clinical sepsis.