CAJ | 학술논문

雷公藤为卫矛科植物，是一种常见的有毒蜜源植物。作为中国传统医学中一种常用中草药，其具有抗炎、免疫抑制等作用，临床广泛用于治疗自身免疫系统疾病。20世纪60年代又将其应用于治疗类风湿性关节炎，因其见效快、疗效确切而备受青睐，并逐渐被西方学者认可，临床应用十分广泛，但时有不良反应发生。近年来，国内外学者对雷公藤做了大量的研究，分析出其毒性成分，并不断探讨使雷公藤制剂减毒增效的方法。该文就雷公藤毒理及减毒方案的研究进展予以综述，以期为相关研究提供参考。
뢰공등위위모과식물，시일충상견적유독밀원식물。작위중국전통의학중일충상용중초약，기구유항염、면역억제등작용，림상엄범용우치료자신면역계통질병。20세기60년대우장기응용우치료류풍습성관절염，인기견효쾌、료효학절이비수청래，병축점피서방학자인가，림상응용십분엄범，단시유불량반응발생。근년래，국내외학자대뢰공등주료대량적연구，분석출기독성성분，병불단탐토사뢰공등제제감독증효적방법。해문취뢰공등독리급감독방안적연구진전여이종술，이기위상관연구제공삼고。
Tripterygium wilfordii Hook .f.,the celastraceae plant is a kind of common poisonous nectariferous plants.As a kind of commonly used Chinese herbal medicine,it has anti-inflammatory and immunosuppressive effect,which is widely used in the clinical treatment of autoimmune disea-ses.It is popularly used for Rheumatoid arthritis in 1960s because of its rapid,exact curative effect, and then gradually accepted by western scholars,the clinical application is very extensive but con-current toxicity.In recent years,a lot of study of tripterygium wilfordii have been done by scholars both at home and abroad,analysing its toxic ingredients, constantly exploring the attenuated and synergistic approaches.This article summarized the study of tripterygium wilfordii toxicology and at-tenuated solutions in recent years,so as to provide reference for related research.