CAJ | 학술논문

microRNA（miRNA）是一类普遍存在的小分子RNA，通常在转录后水平抑制靶基因的表达。 miRNA参与了多种疾病的基因调控并与糖尿病病程的发展有关。糖尿病是最常见的内分泌代谢疾病，糖尿病前期是指一种异常的血糖状态，特征为糖耐量减低和（或）空腹血糖受损。糖尿病前期在最终进展为显性2型糖尿病之前，可以持续相当长的时间，目前关于循环miRNA在2型糖尿病及糖尿病前期中的作用仍需大量研究证实。
microRNA（miRNA）시일류보편존재적소분자RNA，통상재전록후수평억제파기인적표체。 miRNA삼여료다충질병적기인조공병여당뇨병병정적발전유관。당뇨병시최상견적내분비대사질병，당뇨병전기시지일충이상적혈당상태，특정위당내량감저화（혹）공복혈당수손。당뇨병전기재최종진전위현성2형당뇨병지전，가이지속상당장적시간，목전관우순배miRNA재2형당뇨병급당뇨병전기중적작용잉수대량연구증실。
MicroRNAs ( miRNAs) are a family of small nonprotein-coding RNAs.They inhibit the expression of target gene at post-transcriptional level.MiRNAs are involved in gene regulation of various diseases and related on the diabetes development .Diabetes is the most common endocrine met-abolic disease.Pre-diabetes refers to a state of abnormal blood glucose, characteristics of reduce glu-cose tolerance and/or impaired fasting glucose.Pre-diabetes, before eventually developed to overt type 2 diabetes can last a long time.But more studies based on large population are needed to identify the role of circulating miRNA in the type 2 diabetes and pre-diabetes.