CAJ | 학술논문

胃食管反流病的发病机制尚不明确，近年来研究表明脑-肠肽在其发生、发展过程中起重要作用。在胃食管反流病患者中脑-肠肽通过各种不同的机制，对于食管下段括约肌有一定的调节作用，从而参与了胃食管反流病的发生，对于各种脑-肠肽在胃食管反流病中的发病机制的研究，可能对于胃食管反流病的治疗和预后有着重要的意义。将脑-肠肽作为一个新的靶点，也必将给胃食管反流病患者的治疗提供新的方向。
위식관반류병적발병궤제상불명학，근년래연구표명뇌-장태재기발생、발전과정중기중요작용。재위식관반류병환자중뇌-장태통과각충불동적궤제，대우식관하단괄약기유일정적조절작용，종이삼여료위식관반류병적발생，대우각충뇌-장태재위식관반류병중적발병궤제적연구，가능대우위식관반류병적치료화예후유착중요적의의。장뇌-장태작위일개신적파점，야필장급위식관반류병환자적치료제공신적방향。
Pathogenesis of gastroesophageal reflux disease remains unclear,recent studies show that brain gut peptides play an important role in occurrence,development in gastroesophageal reflux disease.In patients with gastroesophageal reflux disease,brain gut peptide have a regulatory role on the lower esophageal sphinc-ter through different mechanisms,which involved in gastroesophageal reflux disease.For the research of vari-ous brain gut peptide in the pathogenesis of gastroesophageal reflux disease,there has great significance for the treatment and prognosis of gastric esophageal reflux disease.The brain -gut peptide as a new target, also provide a new direction for the treatment of gastroesophageal reflux disease patients .