CAJ | 학술논문

目的：观察神经生长因子（ NGF）应用于临床治疗脑出血的疗效。方法选取2013年5月至2013年11月间中国医科大学附属第一医院鞍山医院神经内科收治的76例脑出血患者作为研究对象，按照随机数字表法分为两组，每组38例。常规治疗组给予常规治疗，NGF组在常规治疗基础上给予NGF治疗，每次30μg肌内注射，每日1次，连续2周为1个周期。以美国国立卫生研究院卒中量表（ NIHSS）为标准评价患者的神经功能缺损情况；2周后观察记录并对比两组患者疗效。结果治疗2周后，NGF组NIHSS评分从治疗前的（20．32±11．07）分恢复至（8．29±7．54）分；常规治疗组NIHSS评分从治疗前（19．75±10．84）分恢复至（12．33±9．09）分；NGF组临床疗效好于常规治疗组（P＜0．05）。结论 NGF对脑出血患者的神经损伤具有一定的保护和促进恢复作用，且未出现明显不良反应，有潜力在临床上推广应用。
목적：관찰신경생장인자（ NGF）응용우림상치료뇌출혈적료효。방법선취2013년5월지2013년11월간중국의과대학부속제일의원안산의원신경내과수치적76례뇌출혈환자작위연구대상，안조수궤수자표법분위량조，매조38례。상규치료조급여상규치료，NGF조재상규치료기출상급여NGF치료，매차30μg기내주사，매일1차，련속2주위1개주기。이미국국립위생연구원졸중량표（ NIHSS）위표준평개환자적신경공능결손정황；2주후관찰기록병대비량조환자료효。결과치료2주후，NGF조NIHSS평분종치료전적（20．32±11．07）분회복지（8．29±7．54）분；상규치료조NIHSS평분종치료전（19．75±10．84）분회복지（12．33±9．09）분；NGF조림상료효호우상규치료조（P＜0．05）。결론 NGF대뇌출혈환자적신경손상구유일정적보호화촉진회복작용，차미출현명현불량반응，유잠력재림상상추엄응용。
Objective To study the efficacy of the nerve growth factor(NGF) in clinical treatment of in-tracerebral hemorrhage.Methods 76 samples were collected from patients diagnosed with intracerebral hemorrhage in Department of internal medicine of the First Affiliated Hospital ( Anshan hospital ) of China Medical University , and were divided into 2 groups by table of random number.Each group contained 38 patients.Control group was treated with conventional therapy, while NGF group was treated with additional nerve growth factor(NGF).Giving 30μg intramuscular injectionfor each day and taking 2 weeks as a cycle. Neurologic impairment was evaluated following the standard of national institutes of health stroke scale ( NIH-SS) after two weeks of treatment.Activities of daily living(ADL) was evaluated by the follow up 6 months later.Results After 2 weeks of treatment, NIHSS score of NGF group was turned to (8.29 ±7.54) from (20.32 ±11.07)(before treatment), while NIHSS score ofconventional therapy group was turned to (12.33 ±9.09) from (19.75 ±10.84)(before treatment).The clinical efficacy of NGF group was better than con-ventional therapy group(P<0.05).Conclusion The nerve growth factor has some therapeutic effects in protecting the neuron from damage and promoting recovery, with fewer adverse reactions.It provides a prom-ising way for effective and safe clinical treatment of intracerebral hemorrhage .