CAJ | 학술논문

目的：探讨白细胞介素21受体信使RNA的表达与检测对类风湿关节炎患者的临床应用价值。方法选取2012年3月至2014年4月在三峡大学仁和医院进行检验和治疗的类风湿关节炎患者80例，设为观察组，另外根据一般资料相近原则选择30例健康志愿者相关体检资料作为对照组，根据患者关节功能分为三个等级，分别采样后比较白细胞介素21受体信使 RNA 的表达情况。结果观察组患者IL-21水平为（510．4±66．2） ng／L，明显高于健康对照组的（332．8±30．1） ng／L （t＝13．80，P＜0．05）；三级类风湿性关节炎患者体内 IL-21水平分别为，Ⅰ级（410．5±57．1） ng／L，Ⅱ级（435．8±60．5） ng／L，Ⅲ级及以上（600．8±78．9） ng／L，三个等级比较差异有统计学意义（ F＝14．01，P＜0．05），其中Ⅱ级与Ⅰ级的差异无统计学意义（t＝1．33，P＞0．05），Ⅱ级与Ⅲ级及以上患者的差异有统计学意义（t＝8．53，P＜0．05）。结论 IL-21物质参与了类风湿关节炎的发病过程，故该物质的水平可用于疾病的检测，具有广阔的应用前景。
목적：탐토백세포개소21수체신사RNA적표체여검측대류풍습관절염환자적림상응용개치。방법선취2012년3월지2014년4월재삼협대학인화의원진행검험화치료적류풍습관절염환자80례，설위관찰조，령외근거일반자료상근원칙선택30례건강지원자상관체검자료작위대조조，근거환자관절공능분위삼개등급，분별채양후비교백세포개소21수체신사 RNA 적표체정황。결과관찰조환자IL-21수평위（510．4±66．2） ng／L，명현고우건강대조조적（332．8±30．1） ng／L （t＝13．80，P＜0．05）；삼급류풍습성관절염환자체내 IL-21수평분별위，Ⅰ급（410．5±57．1） ng／L，Ⅱ급（435．8±60．5） ng／L，Ⅲ급급이상（600．8±78．9） ng／L，삼개등급비교차이유통계학의의（ F＝14．01，P＜0．05），기중Ⅱ급여Ⅰ급적차이무통계학의의（t＝1．33，P＞0．05），Ⅱ급여Ⅲ급급이상환자적차이유통계학의의（t＝8．53，P＜0．05）。결론 IL-21물질삼여료류풍습관절염적발병과정，고해물질적수평가용우질병적검측，구유엄활적응용전경。
Objective To investigate the clinical application value of interleukin-21 receptor expression and detection of mRNA in patients with rheumatoid arthritis .Methods 80 patients with rheumatoid arthritis were selected as the observation group , 30 healthy volunteers were selected as control group based on the re-lated data of physical examination.According to the joint function of the patients was divided into three grades, the expression of interleukin 21 receptor messenger mRNA sampling were compared .Results In the observation group, IL-21 was (510.4 ±66.2) ng/L, significantly higher than that of the healthy con-trol group [(332.8 ±30.1 data) ng/L] (t=13.80, P<0.05); three patients with rheumatoid arthritis in vivo IL-21 levels are not the same, the difference between Ⅱ patients and Ⅰ patients had no statistical significance (t=1.33, P>0.05), with statistical significance of II level and III level and above differences of patients (t=8.53, P<0.05).Conclusion IL-21 substances involved in the pathogenesis of rheuma-toid arthritis, the level of material can be used in disease detection, and has broad application prospects.