中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
3期
468-472
,共5页
NALP3炎性体%炎性介质%炎症相关肿瘤
NALP3炎性體%炎性介質%炎癥相關腫瘤
NALP3염성체%염성개질%염증상관종류
NALP3 inflammasome%Inflammatory mediators%Inflammasome-related tumor
NALP3（NACHT-LRR-PYD-containing proteins 3 inflammasome）是NOD样受体（NOD-like receptors，NLRs）蛋白家族中典型代表，有调节机体免疫及调控炎症反应的作用，通过促进多种炎性介质（如IL-1β、IL-6、TNF-α等）释放可增加自身免疫性疾病及非感染性疾病的发生风险，近年来有许多研究表明NALP3炎性体还与肿瘤的发生、逃逸及转移有关，使之成为肿瘤性疾病研究的新热点。本文主要针对NALP3炎性体的结构、激活方式及相关肿瘤疾病做一综述。
NALP3（NACHT-LRR-PYD-containing proteins 3 inflammasome）是NOD樣受體（NOD-like receptors，NLRs）蛋白傢族中典型代錶，有調節機體免疫及調控炎癥反應的作用，通過促進多種炎性介質（如IL-1β、IL-6、TNF-α等）釋放可增加自身免疫性疾病及非感染性疾病的髮生風險，近年來有許多研究錶明NALP3炎性體還與腫瘤的髮生、逃逸及轉移有關，使之成為腫瘤性疾病研究的新熱點。本文主要針對NALP3炎性體的結構、激活方式及相關腫瘤疾病做一綜述。
NALP3（NACHT-LRR-PYD-containing proteins 3 inflammasome）시NOD양수체（NOD-like receptors，NLRs）단백가족중전형대표，유조절궤체면역급조공염증반응적작용，통과촉진다충염성개질（여IL-1β、IL-6、TNF-α등）석방가증가자신면역성질병급비감염성질병적발생풍험，근년래유허다연구표명NALP3염성체환여종류적발생、도일급전이유관，사지성위종류성질병연구적신열점。본문주요침대NALP3염성체적결구、격활방식급상관종류질병주일종술。
NALP3 (NACHT-LRR-PYD-containing proteins 3 inflammasome) is a typical representative of NOD-like receptor (NLRs) protein family which has the function of regulating innate immunity and chronic inflammation. The NALP3 can increase the risk of autoimmune disease and non infectious disease by releasing different types of inflammatory mediators (like IL-1β, IL-6, TNF-α). Our recent research indicates that the NALP3 inflammasome also has the relationship with malignant transformation, tumor escape and tumor transfer. The study of the NALP3 inflammasome becomes hot point in the field of neoplastic disease. In this review, we mainly had a summary on the structure and activation of NALP3, as well as on NALP3 inflammasome-related tumor.
