CAJ | 학술논문

目的：评价新型抗精神病药喹硫平和氟哌啶醇治疗谵妄的临床疗效和安全性。方法计算机检索Embase、Pubmed、中国知网全文数据库、万方数据库2000年1月至2014年10月有关喹硫平和氟哌啶醇治疗谵妄的随机对照试验，并进行Meta分析。结果共纳入3篇关于两种药物治疗谵妄的随机对照试验和1篇前瞻性非随机对照研究。Meta分析显示喹硫平对谵妄患者谵妄评定量表（DRS）评分和临床整体印象量表严重程度评分（CGI-SI）的改善与氟哌啶醇组无统计学差异。喹硫平和氟哌啶醇的锥体外系副反应无统计学差异。结论喹硫平治疗谵妄的疗效和安全性基本与氟哌啶醇相似。由于本Meta分析的存在一定方法学的局限性，还需要更多的含有良好设计方法、样本量足够、高质量的多中心随机对照试验来印证本研究结果的可靠性。
목적：평개신형항정신병약규류평화불고정순치료섬망적림상료효화안전성。방법계산궤검색Embase、Pubmed、중국지망전문수거고、만방수거고2000년1월지2014년10월유관규류평화불고정순치료섬망적수궤대조시험，병진행Meta분석。결과공납입3편관우량충약물치료섬망적수궤대조시험화1편전첨성비수궤대조연구。Meta분석현시규류평대섬망환자섬망평정량표（DRS）평분화림상정체인상량표엄중정도평분（CGI-SI）적개선여불고정순조무통계학차이。규류평화불고정순적추체외계부반응무통계학차이。결론규류평치료섬망적료효화안전성기본여불고정순상사。유우본Meta분석적존재일정방법학적국한성，환수요경다적함유량호설계방법、양본량족구、고질량적다중심수궤대조시험래인증본연구결과적가고성。
ObjectiveTo evaluate the clinical efficacy and safety of quetiapine and haloperidol in treatment of patients with delirium.MethodsWe searched in Embase, Pubmed, WanFang database and CNKI to identify studies on prospective trials about quetiapine and haloperidol in treatment of patients with delirium from January 2000 to October 2014. A Meta-analysis was performed.Results3 RCTs and one prospective observational study were included. There was no significant difference in improvement of DRS and CGI-SI scores of delirious patients between quetiapine and haloperidol group; no significant difference in incidence rate of adverse effects in extrapyramidal system between two groups (P<0.05).ConclusionQuetiapine and haloperidol were equally efficacious and safe in the treatment of delirium. However, double-blind, randomized and multi-center studies are needed.