CAJ | 학술논문

目的：检测强直性脊柱炎( AS)患者D-二聚体的水平,探讨其在AS中的临床意义。方法2013年3—10月收治的AS患者60例设为AS组,将Bath疾病活动度指数( BASDAI)≥4的38例设为高疾病活动度亚组,<4的22例设为低疾病活动度亚组。2013年9月的健康体检者60例设为对照组。分别检测外周血D-二聚体水平,比较其差异性；分析AS患者D-二聚体水平与BASDAI、年龄、性别、血沉、C反应蛋白、血脂、凝血功能的相关性。结果 AS组血浆D-二聚体水平显著高于对照组(P<0．01),高疾病活动度亚组D-二聚体水平显著高于低疾病活动度亚组(P<0．01)。 D-二聚体水平与BASDAI、血沉、C反应蛋白、脂蛋白α和纤维蛋白原含量呈正相关(P<0．05,P<0．01),与纤维蛋白时间、载脂蛋白-A呈负相关(P<0．01)。结论 D-二聚体在AS发病及疾病转归中可能发挥重要作用,有望作为AS病情活动的血清标志物。
목적：검측강직성척주염( AS)환자D-이취체적수평,탐토기재AS중적림상의의。방법2013년3—10월수치적AS환자60례설위AS조,장Bath질병활동도지수( BASDAI)≥4적38례설위고질병활동도아조,<4적22례설위저질병활동도아조。2013년9월적건강체검자60례설위대조조。분별검측외주혈D-이취체수평,비교기차이성；분석AS환자D-이취체수평여BASDAI、년령、성별、혈침、C반응단백、혈지、응혈공능적상관성。결과 AS조혈장D-이취체수평현저고우대조조(P<0．01),고질병활동도아조D-이취체수평현저고우저질병활동도아조(P<0．01)。 D-이취체수평여BASDAI、혈침、C반응단백、지단백α화섬유단백원함량정정상관(P<0．05,P<0．01),여섬유단백시간、재지단백-A정부상관(P<0．01)。결론 D-이취체재AS발병급질병전귀중가능발휘중요작용,유망작위AS병정활동적혈청표지물。
Objective To detect D-dimer level in ankylosing spondylitis ( AS) patients, and to discuss its clini-cal significance in AS. Methods A total of 60 AS patients admitted during March and October in 2013 were chosen as AS group, in which 38 patients with Bath AS disease activity index ( BASDAI) ≥4 were as high disease activity sub-group, and other 22 patients with BASDAI <4 were as low disease activity subgroups. A total of 60 patients taking medi-cal examination in September 2013 were chosen as control group. The D-dimer levels in all cases were detected respec-tively, and the differences were also compared. The correlations between D- dimer level with BASDAI, age, gender, ESR (erythrocyte sedimentation rate), CRP(C-reactive protein), blood fat and blood clotting function were analyzed. Results plasma D-dimer level In AS group was significantly higher than that in control group (P<0. 01);plasma D-dimer level in high disease activity subgroup was significantly higher than that in low disease activity subgroup ( P <0. 01 ) . The D-dimer level had positive correlations with BASDAI, ESR, CRP, hs-CRP ( high-sensitivity C-reactive pro-tein), lipoprotein α and fibrinogen content (P<0. 05, P<0. 01), while the D- dimer level had negative correlations with fibrin time and apolipoprotein-A (P<0. 01). Conclusion D-dimer may play an important role in the pathogenesis and disease outcome of AS, and may be used as a serum marker of disease activity.