CAJ | 학술논문

目的：分析血糖波动与老年2型糖尿病患者认知功能障碍的关系。方法选取2010年10月—2014年2月收治的老年糖尿病患者183例，所有患者均接受72 h动态血糖监测( CGMS)，根据监测结果计算日内平均血糖波动幅度( MAGE)、日间血糖波动幅度( MODD)、血糖水平标准差( SDBG)、平均餐后血糖波动幅度( MPPGE)。 CGMS测定期间所有患者接受蒙特利尔认知评估量表( MoCA)进行认知功能测定，根据测定结果分为认知障碍组85例( A组)和非认知障碍组98例( B组)。结果两组间空腹血糖、餐后2 h血糖、糖化血红蛋白、MAGE、SDBG、MPPGE、MODD的差异具有统计学意义(P<0．05)；多因素逐步回归分析MAGE、SDBG与认知障碍呈显著相关性(P<0．05)。结论血糖波动对老年2型糖尿病患者认知功能产生影响，其中以MAGE、SDBG关系最为密切。
목적：분석혈당파동여노년2형당뇨병환자인지공능장애적관계。방법선취2010년10월—2014년2월수치적노년당뇨병환자183례，소유환자균접수72 h동태혈당감측( CGMS)，근거감측결과계산일내평균혈당파동폭도( MAGE)、일간혈당파동폭도( MODD)、혈당수평표준차( SDBG)、평균찬후혈당파동폭도( MPPGE)。 CGMS측정기간소유환자접수몽특리이인지평고량표( MoCA)진행인지공능측정，근거측정결과분위인지장애조85례( A조)화비인지장애조98례( B조)。결과량조간공복혈당、찬후2 h혈당、당화혈홍단백、MAGE、SDBG、MPPGE、MODD적차이구유통계학의의(P<0．05)；다인소축보회귀분석MAGE、SDBG여인지장애정현저상관성(P<0．05)。결론혈당파동대노년2형당뇨병환자인지공능산생영향，기중이MAGE、SDBG관계최위밀절。
Objective To analyze the relationship between the glucose fluctuation and cognitive dysfunction in elderly patients with type 2 diabetes mellitus. Methods A total of 183 elderly patients with type 2 diabetes mellitus during October 2010 and February 2014 were monitored for 72 h with the continuous glucose monitoring system ( CGMS) , and the values of mean amplitude of glycemic excursions ( MAGE ) , absolute means of daily difference ( MODD ) , standard deviation of blood glucose ( SDBG ) and mean postprandial glucose excursion ( MPPGE ) were calculated according to the monitoring results. All the patients were detected with Montreal Cognitive Assessment ( MoCA) scale for cognitive function during the CGMS monitoring, and were divided into cognitive dysfunction group (group A, n=85) and non-cognitive dysfunction group (group B, n=98) according to MoCA score. Results The differences in fasting plasma glucose, 2 h postprandial glucose, glycated hemoglobin (HbAlc), MAGE, SDBG, MPPGE and MODD in the two groups were statistically significant (P<0. 05);multiple linear regression analysis showed that MAGE and SDBG were signifi-cantly associated with cognitive dysfunction (P <0. 05). Conclusion Glucose fluctuation has significant correlation with cognitive function in elderly patients with type 2 diabetes mellitus, in which MAGE and SDBG are most correlated.