解放军医药杂志
解放軍醫藥雜誌
해방군의약잡지
MEDICAL&PHARMACEUTICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY
2015年
1期
78-81
,共4页
胃肿瘤%埃兹蛋白%Bcl-2%Bax%免疫组织化学%基因表达调控,肿瘤
胃腫瘤%埃玆蛋白%Bcl-2%Bax%免疫組織化學%基因錶達調控,腫瘤
위종류%애자단백%Bcl-2%Bax%면역조직화학%기인표체조공,종류
Stomach neoplasms%Ezrin%Bcl-2,bax%Immunohistochemistry%Gene expression regulation,neo-plastic
目的：探讨埃兹( Ezrin)蛋白、Bcl-2/Bax在胃癌组织中的表达情况,并分析Ezrin与临床病理特征及预后的关系。方法选择2006年10月—2009年10月收治的胃癌患者的癌组织石蜡标本52例,其中36例有癌旁组织标本。对标本进行免疫组化染色,检测Ezrin、Bcl-2、Bax的表达情况,分析Ezrin与临床病理特征的关系。结果胃癌组织中Ezrin、Bcl-2表达均较癌旁组织增强(P<0．05),Bax在胃癌和癌旁组织中表达无明显差异(P>0．05)；胃癌组织中Ezrin与Bcl-2表达存在正相关关系,Bcl-2与Bax表达存在负相关关系( P<0．05)；Ezrin与Bax表达无明显相关关系(P>0．05)。 Ezrin表达与肿瘤浸润深度、临床分期、淋巴结转移有关(P<0．05)；Ezrin表达阳性患者的预后较差。结论 Ezrin蛋白在胃癌组织中表达增高,该蛋白与临床病理特征有关,且可以作为预后判断指标；Ezrin蛋白在胃癌中的作用可能与调节Bcl-2有关。
目的：探討埃玆( Ezrin)蛋白、Bcl-2/Bax在胃癌組織中的錶達情況,併分析Ezrin與臨床病理特徵及預後的關繫。方法選擇2006年10月—2009年10月收治的胃癌患者的癌組織石蠟標本52例,其中36例有癌徬組織標本。對標本進行免疫組化染色,檢測Ezrin、Bcl-2、Bax的錶達情況,分析Ezrin與臨床病理特徵的關繫。結果胃癌組織中Ezrin、Bcl-2錶達均較癌徬組織增彊(P<0．05),Bax在胃癌和癌徬組織中錶達無明顯差異(P>0．05)；胃癌組織中Ezrin與Bcl-2錶達存在正相關關繫,Bcl-2與Bax錶達存在負相關關繫( P<0．05)；Ezrin與Bax錶達無明顯相關關繫(P>0．05)。 Ezrin錶達與腫瘤浸潤深度、臨床分期、淋巴結轉移有關(P<0．05)；Ezrin錶達暘性患者的預後較差。結論 Ezrin蛋白在胃癌組織中錶達增高,該蛋白與臨床病理特徵有關,且可以作為預後判斷指標；Ezrin蛋白在胃癌中的作用可能與調節Bcl-2有關。
목적：탐토애자( Ezrin)단백、Bcl-2/Bax재위암조직중적표체정황,병분석Ezrin여림상병리특정급예후적관계。방법선택2006년10월—2009년10월수치적위암환자적암조직석사표본52례,기중36례유암방조직표본。대표본진행면역조화염색,검측Ezrin、Bcl-2、Bax적표체정황,분석Ezrin여림상병리특정적관계。결과위암조직중Ezrin、Bcl-2표체균교암방조직증강(P<0．05),Bax재위암화암방조직중표체무명현차이(P>0．05)；위암조직중Ezrin여Bcl-2표체존재정상관관계,Bcl-2여Bax표체존재부상관관계( P<0．05)；Ezrin여Bax표체무명현상관관계(P>0．05)。 Ezrin표체여종류침윤심도、림상분기、림파결전이유관(P<0．05)；Ezrin표체양성환자적예후교차。결론 Ezrin단백재위암조직중표체증고,해단백여림상병리특정유관,차가이작위예후판단지표；Ezrin단백재위암중적작용가능여조절Bcl-2유관。
Objective To investigate expressions of Ezrin and Bcl-2/Bax in gastric carcinoma tissues and to ana-lyze the relationship between Ezrin and clinicopathological characteristics and its prognosis. Methods A total of 52 par-affin samples from cancer tissues of inpatients with gastric carcinoma during 2006 October and 2009 October were select-ed, which included 36 cases of adjacent cancerous tissues. Immunohistochemical staining was performed to detect the ex-pressions of Ezrin, Bcl-2 and Bax, And the relationship between Ezrin and clinicopathological characteristics were also analyzed. Results Expressions of Ezrin and Bcl-2 were stronger in gastric carcinoma tissues than those in adjacent can-cerous tissues (P<0. 05), and there was no significant difference in Bax expression between gastric carcinoma tissues and adjacent cancerous tissues (P>0. 05);there was a positive relationship between Ezrin and Bcl-2 expressions in gas-tric carcinoma tissues, and a negative relationship was found between Bcl-2 and Bax expressions (P<0. 05);there was no significant relationship between Ezrin and Bax expressions (P>0. 05). Ezrin expression was related to tumor infiltra-ting depth, clinical stages and lymph node metastasis (P<0. 05);the patients with positive expression of Ezrin had poor prognosis. Conclusion Relationship exists between overexpression of Ezrin and some clinicopathological characteristics of gastric cancer, and Ezrin may be used as a judgement index for prognosis. Ezrin may affect gastric cancer by regulating Bcl-2 expression.
