现代仪器与医疗
現代儀器與醫療
현대의기여의료
Modern Instrument and Medical Treatment
2015年
1期
33-35
,共3页
三维适形%FOLFOX方案%直肠癌
三維適形%FOLFOX方案%直腸癌
삼유괄형%FOLFOX방안%직장암
Three-dimensional conformal radiotherapy%FOLFOX%Rectal cancer
目的：探讨术前三维适形放疗联合FOLFOX方案治疗直肠癌的临床疗效及治疗安全性。方法：选取2008年2月～2012年1月在我科治疗而且病理证实为局部晚期直肠癌患者65例，随机分为适形放疗加化疗组（观察组）35例，常规放疗加化疗组（对照组）30例，观察并比较两组的临床疗效和不良反应情况。结果：两组总有效率(CR+PR)分别是63.3%和82.9%。术前肿瘤分期明显降低，治疗后原诊断为T 3期的35例患者中6例降为T 1期，13例降为T 2期，16例仍为T 3期；其侵犯淋巴结均有缩小，其中12例转阴。对照组放射性膀胱炎、皮肤反应和放射性直肠炎的发生率高于观察组(P＜0.05)。结论：术前三维适形放疗联合FOLFOX方案化疗治疗局部晚期直肠癌的安全有效的方法，值得临床应用。
目的：探討術前三維適形放療聯閤FOLFOX方案治療直腸癌的臨床療效及治療安全性。方法：選取2008年2月～2012年1月在我科治療而且病理證實為跼部晚期直腸癌患者65例，隨機分為適形放療加化療組（觀察組）35例，常規放療加化療組（對照組）30例，觀察併比較兩組的臨床療效和不良反應情況。結果：兩組總有效率(CR+PR)分彆是63.3%和82.9%。術前腫瘤分期明顯降低，治療後原診斷為T 3期的35例患者中6例降為T 1期，13例降為T 2期，16例仍為T 3期；其侵犯淋巴結均有縮小，其中12例轉陰。對照組放射性膀胱炎、皮膚反應和放射性直腸炎的髮生率高于觀察組(P＜0.05)。結論：術前三維適形放療聯閤FOLFOX方案化療治療跼部晚期直腸癌的安全有效的方法，值得臨床應用。
목적：탐토술전삼유괄형방료연합FOLFOX방안치료직장암적림상료효급치료안전성。방법：선취2008년2월～2012년1월재아과치료이차병리증실위국부만기직장암환자65례，수궤분위괄형방료가화료조（관찰조）35례，상규방료가화료조（대조조）30례，관찰병비교량조적림상료효화불량반응정황。결과：량조총유효솔(CR+PR)분별시63.3%화82.9%。술전종류분기명현강저，치료후원진단위T 3기적35례환자중6례강위T 1기，13례강위T 2기，16례잉위T 3기；기침범림파결균유축소，기중12례전음。대조조방사성방광염、피부반응화방사성직장염적발생솔고우관찰조(P＜0.05)。결론：술전삼유괄형방료연합FOLFOX방안화료치료국부만기직장암적안전유효적방법，치득림상응용。
Objective:To evaluate the efifcacy and compliance of neoadjuvant three-dimensional conformal radiotherapy(3-DCRT) combined with FOLFOX regimen in the management of locally advanced rectal cancer.Method: 65 patients with rectal cancer after radical excision were enrolled whose treated in 2008.2~2012.1. They were randomly divided into two groups, 35 patients in radiochemotherapy with3-DCRT group(observed group) and 30 patients in radiochemotherapy group(control group). The clinical efifcacy and side effects were observed and compared.Results:The overall response rate was82.9% in 3-DCRT group and 63.3% in control group,Tumor stages were downstaged signiifcantly. 6 patients in 35 cases whose original diagnosis for T3 downstaged to T1 stage,13 patients downstageed to T2 staged and the lymph nodes involved reduced, including 12 cases turned to negative. The incidences of radiocystitis, skin reaction and radiation proctitis were lower in 3- DCRT group than those in control group(P<0.05).Conclusion:Concurrent three-dimensional conformal radiotherapy and chemotherapy might be safe and effective in the treatment for rectal cancer with local recurrence postoperation, and may improve survival rate with less toxicity. It is worthy of clinical application.
