CAJ | 학술논문

目的：系统评价托吡酯对奥氮平所致体质量增高的干预。方法计算机检索Cochrane图书馆、Pubmed、EMbase、万方数据库、中国知网、维普中文期刊数据库、中国学位论文全文数据库，收集1998～2013年关于托吡酯干预奥氮平所致体质量增高的随机对照试验（RCT）。由2位研究者独立进行文献筛选、资料提取和方法学质量评价后，采用RevMan5．1软件进行Meta分析。结果11篇RCT文献满足纳入标准，共549名受试者。Meta分析结果显示：托吡酯减轻奥氮平所致体质量增高优于对照组，其差异有统计学意义，MD为－3．68，95％CI：－5．16～－2．19，Z＝4．86，P＜0．01。结论托吡酯能减轻奥氮平所致的体质量增高。
목적：계통평개탁필지대오담평소치체질량증고적간예。방법계산궤검색Cochrane도서관、Pubmed、EMbase、만방수거고、중국지망、유보중문기간수거고、중국학위논문전문수거고，수집1998～2013년관우탁필지간예오담평소치체질량증고적수궤대조시험（RCT）。유2위연구자독립진행문헌사선、자료제취화방법학질량평개후，채용RevMan5．1연건진행Meta분석。결과11편RCT문헌만족납입표준，공549명수시자。Meta분석결과현시：탁필지감경오담평소치체질량증고우우대조조，기차이유통계학의의，MD위－3．68，95％CI：－5．16～－2．19，Z＝4．86，P＜0．01。결론탁필지능감경오담평소치적체질량증고。
Objective To assess whether topiramate prevents body weight gain in patients with olanzapine .Methods The ran‐domized controlled trials(RCTs) about topiramate for prevention of weight gain with olanzapine from 1998 to 2013 were searched in the Cochrane Library ,Pubmed ,EMbase ,WanFang Data ,CNKI and VIP .Two reviewers independently screened the literatures ,ex‐tracted the data ,and evaluated the methodological quality .Then Meta‐analyses were conducted by using RevMan 5 .1 software .Re‐sults The total of 11 RCTs were included .Among the 549 patients were involved .The results of Meta‐analyses showed that the ef‐ficacy of the topiramate group was superior to that of the control group in lessen body mass with significant difference (MD= -3 .68 ,95% CI:-5 .16- -2 .19 ,Z=4 .86 ,P<0 .01) .Conclusion Topiramate addition therapy is effective in attenuating olanzapine‐induced weight gain .