CAJ | 학술논문

目的：研究血浆激肽释放酶（KLKB1）在成人隐匿性自身免疫性糖尿病（LADA）、经典1型糖尿病（T1DM）、2型糖尿病（T2DM）和健康成人中的水平，并结合其他指标分析其与LADA的关系。方法分别检测LADA组、T1DM组、T2DM组、健康对照组（NC组）血浆样本中KLKB1、糖化血红蛋白（HbA1c）、空腹血糖（FPG）、餐后2h血糖（2hPG）、空腹C肽（FCP）、餐后2hC肽（2hCP）、谷氨酸脱羧酶抗体（GADA）等指标，并对检测结果进行统计学分析。结果LADA组与其他各组在FPG（T2DM组除外）、2hPG、HbA1c、FCP、2hCP指标方面差异有统计学意义（P＜0．05）。LADA组与其他各组（T1DM组除外）GADA的差异有统计学意义（P＜0．05）；KLKB1在LADA组血浆中的含量明显高于T2DM组和NC组，差异有统计学意义（P＜0．05）；KLKB1与FCP、HbA1c、FPG、2hPG相关（P＜0．05），而与年龄、病程、2hCP无关（P＞0．05）。ROC曲线进一步分析显示，单独应用KLKB1对LADA进行诊断或鉴别诊断具有一定的局限性。结论KLKB1对判断LADA发病风险和早期诊断LADA有一定意义，可在LADA高危人群中结合其他指标进行LADA的筛选和监控。
목적：연구혈장격태석방매（KLKB1）재성인은닉성자신면역성당뇨병（LADA）、경전1형당뇨병（T1DM）、2형당뇨병（T2DM）화건강성인중적수평，병결합기타지표분석기여LADA적관계。방법분별검측LADA조、T1DM조、T2DM조、건강대조조（NC조）혈장양본중KLKB1、당화혈홍단백（HbA1c）、공복혈당（FPG）、찬후2h혈당（2hPG）、공복C태（FCP）、찬후2hC태（2hCP）、곡안산탈최매항체（GADA）등지표，병대검측결과진행통계학분석。결과LADA조여기타각조재FPG（T2DM조제외）、2hPG、HbA1c、FCP、2hCP지표방면차이유통계학의의（P＜0．05）。LADA조여기타각조（T1DM조제외）GADA적차이유통계학의의（P＜0．05）；KLKB1재LADA조혈장중적함량명현고우T2DM조화NC조，차이유통계학의의（P＜0．05）；KLKB1여FCP、HbA1c、FPG、2hPG상관（P＜0．05），이여년령、병정、2hCP무관（P＞0．05）。ROC곡선진일보분석현시，단독응용KLKB1대LADA진행진단혹감별진단구유일정적국한성。결론KLKB1대판단LADA발병풍험화조기진단LADA유일정의의，가재LADA고위인군중결합기타지표진행LADA적사선화감공。
Objective To investigate the plasma expression of plasma prekallikrein(KLKB1)in latent autoimmune diabetes in a‐dults(LADA),type1diabetes(T1DM),type2diabetes(T2DM)andhealthypeople,anditsrelationshipwithLADAincombination with other indicators .Methods Among the four groups ,KLKB1 ,glycosylated hemoglobin(HbA1c) ,fasting blood glucose(FPG) ,2 h postprandial plasma glucose(2 h PG) ,Fasting c‐peptide(FCP) ,2 h postprandial C peptide(2 h CP) ,and glutamic acid decarboxy‐lase antibody(GADA)were detected respectively .And the detection results were analyzed by statistics .Results By comparison , there were statistically significant difference between LADA group and other groups on FPG(except for T2DM group) ,2 h PG , HbA1c ,FCP and 2 h CP(P< 0 .05) .And except for T1DM group ,there was statistically significant difference between LADA group and other groups on GADA ,too(P<0 .05) .The plasma expression of KLKB1 in LADA was significantly higher than those in T2DM group and NC group(P<0 .05) .The levels of KLKB1 was related with FCP、HbA1c、FPG、2 h PG(P<0 .05) ,and it was not related with age ,course ,and 2 h CP(P>0 .05) .Receiver operating characteristic (ROC) showed that only using KLKB1 to di‐agnose LADA had its limitation .Conclusion KLKB1 could be used as a clinical indicator to predict the onset of LADA to a certain degree .We could screen for LADA by using KLKB1 and other indicators in people at high risk .