CAJ | 학술논문

目的：研究壮药白花九里明水、醇提取物对耐甲氧西林金黄色葡萄球菌（ MR-SA）体外抗菌的作用，为临床治疗MRSA感染提供新的途径。方法制备壮药白花九里明水、醇提取物，采用纸片扩散法对临床分离的MRSA菌株进行体外抑菌实验，肉汤稀释法测定最小抑菌浓度（ MIC）和最小杀菌浓度（ MBC）。结果壮药白花九里明的水提取物抑菌圈直径为18～24 mm，醇提取物抑菌圈直径为11～18 mm；水提取物的MIC为31．25～250 mg／mL、MBC为31．25～250 mg／mL，醇提取物的MIC为31．25～250 mg／mL、MBC为62．5～500 mg／mL。结论壮药白花九里明水、醇提取物对MRSA菌株有较好的抑制作用。
목적：연구장약백화구리명수、순제취물대내갑양서림금황색포도구균（ MR-SA）체외항균적작용，위림상치료MRSA감염제공신적도경。방법제비장약백화구리명수、순제취물，채용지편확산법대림상분리적MRSA균주진행체외억균실험，육탕희석법측정최소억균농도（ MIC）화최소살균농도（ MBC）。결과장약백화구리명적수제취물억균권직경위18～24 mm，순제취물억균권직경위11～18 mm；수제취물적MIC위31．25～250 mg／mL、MBC위31．25～250 mg／mL，순제취물적MIC위31．25～250 mg／mL、MBC위62．5～500 mg／mL。결론장약백화구리명수、순제취물대MRSA균주유교호적억제작용。
Objective It is to explore the antibacterial effect of water, alcohol extract of extractive Blumea megacephala ( Randeria) chamg et Tseng against methicillin-resistant Staphylococcus aureus ( MRSA) in vi-tro, thus to provide a new way for the clinical treatment of MRSA infection .Methods Water, alcoholextraction of Blumea megacephala ( Randeria) chamg et Tseng was prepared, ant-ibacterial experiment in vitro against Strains of methicillin-resistant Staphylococcus a-ureus isolated from clinic was performed on by the conventional agar diffusion method, minimum inhibitory conc-entration ( MIC) and mini-mal bactericidal concentration ( MBC) were determined by double dilution method.Results Bacteriostatic circle diameter of water extract of Blumea megacephala ( Randeria) chamg et Tseng was 18-24 mm, and that of alcohol extract was 11-18 mm , MIC of water extract was 31.25-250 mg/mL, MBC was 31.25-250 mg/mL, MIC of alcohol extract was 31.25-250 mgm/L , its MBC was 62.5-500 mg/mL.Conclusoi n Water, alcohol extract of Blumea megacephala ( Randeria) chamg et Tseng have good inhibitory effect against methicillin-resistant Staphylococcus aureus strains.