重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2015年
2期
177-179
,共3页
肺疾病%肺总量%敏感性与特异性%肺功能非特异性表现%呼吸功能%临床特点
肺疾病%肺總量%敏感性與特異性%肺功能非特異性錶現%呼吸功能%臨床特點
폐질병%폐총량%민감성여특이성%폐공능비특이성표현%호흡공능%림상특점
lung diseases%total lung capacity%sensitivity and specificity%lung function nonspecific performance%respiratory func-tion%clinical characteristics
目的：对肺功能非特异性表现（NSP）患者的临床特点进行研究，为其临床研究提供可参考依据。方法选择2013年1月至2014年6月青岛经济技术开发区第一人民医院行肺功能检查的120例受试者作为研究对象，根据肺功能表现分为NSP组（n＝20）与肺功能正常组（n＝100），详细记录其肺功能指标，对其临床特点进行分析。并筛选出NSP发生的相关因素，应用Lo‐gistic回归分析进行多因素回归分析。结果正常组肺功能指标第一秒肺呼气容积（FEVl）、肺活量（VC）、肺总量（TLC）、用力肺活量（FVC）、最大自主通气量（MVV）、FEVl／FVC均明显高于NSP组，而RV／TCL低于NSP组，差异均有统计学意义（P＜0．05）。NSP组患者的临床可表现为阻塞性和（或）限制性疾病，但9例患者无肺部疾病。单因素分析显示NSP组年龄、BMI、吸烟史、吸烟量、阻塞性疾病、限制性疾病均明显高于正常组，两组比较差异有统计学意义（P＜0．05）。多因素分析显示年龄大、BMI高、既往吸烟史、存在阻塞性疾病及限制性疾病是NSP发生的独立危险因素（P＜0．05）。结论高龄、吸烟、肥胖可增加NSP发生的风险，临床上NSP可表现为阻塞性及限制性通气功能障碍的特点，在临床实际中需要积极鉴别。
目的：對肺功能非特異性錶現（NSP）患者的臨床特點進行研究，為其臨床研究提供可參攷依據。方法選擇2013年1月至2014年6月青島經濟技術開髮區第一人民醫院行肺功能檢查的120例受試者作為研究對象，根據肺功能錶現分為NSP組（n＝20）與肺功能正常組（n＝100），詳細記錄其肺功能指標，對其臨床特點進行分析。併篩選齣NSP髮生的相關因素，應用Lo‐gistic迴歸分析進行多因素迴歸分析。結果正常組肺功能指標第一秒肺呼氣容積（FEVl）、肺活量（VC）、肺總量（TLC）、用力肺活量（FVC）、最大自主通氣量（MVV）、FEVl／FVC均明顯高于NSP組，而RV／TCL低于NSP組，差異均有統計學意義（P＜0．05）。NSP組患者的臨床可錶現為阻塞性和（或）限製性疾病，但9例患者無肺部疾病。單因素分析顯示NSP組年齡、BMI、吸煙史、吸煙量、阻塞性疾病、限製性疾病均明顯高于正常組，兩組比較差異有統計學意義（P＜0．05）。多因素分析顯示年齡大、BMI高、既往吸煙史、存在阻塞性疾病及限製性疾病是NSP髮生的獨立危險因素（P＜0．05）。結論高齡、吸煙、肥胖可增加NSP髮生的風險，臨床上NSP可錶現為阻塞性及限製性通氣功能障礙的特點，在臨床實際中需要積極鑒彆。
목적：대폐공능비특이성표현（NSP）환자적림상특점진행연구，위기림상연구제공가삼고의거。방법선택2013년1월지2014년6월청도경제기술개발구제일인민의원행폐공능검사적120례수시자작위연구대상，근거폐공능표현분위NSP조（n＝20）여폐공능정상조（n＝100），상세기록기폐공능지표，대기림상특점진행분석。병사선출NSP발생적상관인소，응용Lo‐gistic회귀분석진행다인소회귀분석。결과정상조폐공능지표제일초폐호기용적（FEVl）、폐활량（VC）、폐총량（TLC）、용력폐활량（FVC）、최대자주통기량（MVV）、FEVl／FVC균명현고우NSP조，이RV／TCL저우NSP조，차이균유통계학의의（P＜0．05）。NSP조환자적림상가표현위조새성화（혹）한제성질병，단9례환자무폐부질병。단인소분석현시NSP조년령、BMI、흡연사、흡연량、조새성질병、한제성질병균명현고우정상조，량조비교차이유통계학의의（P＜0．05）。다인소분석현시년령대、BMI고、기왕흡연사、존재조새성질병급한제성질병시NSP발생적독립위험인소（P＜0．05）。결론고령、흡연、비반가증가NSP발생적풍험，림상상NSP가표현위조새성급한제성통기공능장애적특점，재림상실제중수요적겁감별。
Objective To analyze the characteristics of pulmonary function and the clinical significance of non‐specific pattern (NSP) ,and provide basis for the clinical research .Methods A total of 120 pulmonary function tests of adult patients from January 2013 to June 2014 were selected and divided into NSP group(n=20) and normal lung function group(n=100) according to their lung function behavior .The pulmonary function test results ,clinical diagnosis and radiological manifestations were analyzed .The relevant factors affecting NSP occurred were selected and logistic regression analysis was used to analyze multiple factors .Results The FEVl ,VC ,TLC ,FVC ,MVV and FEVl/FVC in normal group were significantly higher than that of NSP group and the RV/TCL was lower than NSP group ,the difference was statistically significant (P<0 .05) .Patients in NSP group were with obstructive and (or) restrictive clinical manifestations .There were 9 patients were without lung disease .Univariate analysis showed that age , BMI ,smoking history ,smoking ,obstructive diseases ,and restrictive disease in NSP group were significantly higher than that in nor‐mal group ,the difference were statistically significant (P<0 .05) .Multivariate analysis showed that age ,BMI ,history of smoking , obstructive diseases and restrictive disease were independent risk factors for NSP (P<0 .05) .Conclusion Old age ,smoking and o‐besity could increase the incidence rate of NSP .The clinical characteristics include obstructive and restrictive ventilation defects ,and need to be identified positively .
