CAJ | 학술논문

目的：探讨莫沙必利治疗功能性消化不良（FD）及近端胃舒张和胃排空功能的临床疗效。方法选择在该院治疗的FD患者102例，随机分为莫沙必利组（观察组）和吗丁啉多潘立酮片组（对照组）各51例，观察两组的临床疗效，采用LOGIQ‐GE‐200型诊断仪检测治疗前、后近端胃舒张和胃排空功能。结果观察组临床有效率为86．27％，明显高于对照组的64．71％，两组比较差异有统计学意义（P＜0．05）；观察组胃底气体评分和近端胃排空率均显著优于对照组（P＜0．05）；观察组服药后近端胃排空明显优于对照组（P＜0．05）；观察组不良反应发生率为3．9％，与对照组比较差异无统计学意义（P＞0．05）。结论莫沙必利治疗FD临床效果优于吗丁琳，且能显著改善患者的近端胃舒张以及胃排空功能。
목적：탐토막사필리치료공능성소화불량（FD）급근단위서장화위배공공능적림상료효。방법선택재해원치료적FD환자102례，수궤분위막사필리조（관찰조）화마정람다반립동편조（대조조）각51례，관찰량조적림상료효，채용LOGIQ‐GE‐200형진단의검측치료전、후근단위서장화위배공공능。결과관찰조림상유효솔위86．27％，명현고우대조조적64．71％，량조비교차이유통계학의의（P＜0．05）；관찰조위저기체평분화근단위배공솔균현저우우대조조（P＜0．05）；관찰조복약후근단위배공명현우우대조조（P＜0．05）；관찰조불량반응발생솔위3．9％，여대조조비교차이무통계학의의（P＞0．05）。결론막사필리치료FD림상효과우우마정림，차능현저개선환자적근단위서장이급위배공공능。
Objective To investigate mosapride in the treatment of functional dyspepsia(FD) and its effect on proximal stomach and gastric emptying function .Methods One hundred and two patients diagnosed of functional dyspepsia in our hospital were ran‐domly divided into observation group (with treatment of mosapride) and control group(with treatment of domperidone) ,and 51 ca‐ses were in each group .The clinical efficacy was observed ,and the LOGIQ‐GE2000 diagnostic apparatus were used to detect the de‐termination of proximal stomach and gastric emptying function before and after treatment .Results The clinical effective rate of the observation group was 86 .27% ,significantly higher than that of the control group(64 .71% ) .The difference was statistically signif‐icant between them(P<0 .05);proximal gastric scores and rate of fundus gas emptying of the observation group were significantly better than those in the control group (P<0 .05);proximal gastric emptying of the observation group was better than that of the control group after taking medicine(P<0 .05);rate of side effect in observed group was 3 .9% ,which compared with control group showed no significant difference (P>0 .05) .Conclusion Mosapride in treatment of functional dyspepsia is better than domperi‐done ,and it could significantly improve the patient′s proximal stomach and the function of gastric motility .