重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2015年
2期
235-236,240
,共3页
王玉丰%羊轶驹%林玲%伍勇%唐青蓝%郑志昂%田秀娟%李志霞%孙少青%代霁虹%邢晓为
王玉豐%羊軼駒%林玲%伍勇%唐青藍%鄭誌昂%田秀娟%李誌霞%孫少青%代霽虹%邢曉為
왕옥봉%양질구%림령%오용%당청람%정지앙%전수연%리지하%손소청%대제홍%형효위
婴儿,新生%唐氏综合征%发生率
嬰兒,新生%唐氏綜閤徵%髮生率
영인,신생%당씨종합정%발생솔
infant,newborn%Down syndrome%incidence
目的：了解三亚地区活产婴儿唐氏综合征（DS）的发生率，并探讨其相关影响因素。方法将三亚地区住院分娩的新生儿共25032例纳入调查对象，通过外周血染色体分析对临床疑似为DS的患儿进行确诊。同时收集患儿及其双亲的临床资料，计算该地区DS发生率，并分析各相关发病因素。结果该地区DS总的发生率为9．59／万，其中汉族为8．34／万，黎族为14．42／万；DS患儿母亲平均育龄为29．8岁，DS发生率随母龄增长呈上升趋势。患儿母亲孕前有毒物、药物等“暴露”史者占45．8％。结论三亚地区DS发生率较高，提高该地区妇女孕期唐氏筛查及产前诊断率十分必要。
目的：瞭解三亞地區活產嬰兒唐氏綜閤徵（DS）的髮生率，併探討其相關影響因素。方法將三亞地區住院分娩的新生兒共25032例納入調查對象，通過外週血染色體分析對臨床疑似為DS的患兒進行確診。同時收集患兒及其雙親的臨床資料，計算該地區DS髮生率，併分析各相關髮病因素。結果該地區DS總的髮生率為9．59／萬，其中漢族為8．34／萬，黎族為14．42／萬；DS患兒母親平均育齡為29．8歲，DS髮生率隨母齡增長呈上升趨勢。患兒母親孕前有毒物、藥物等“暴露”史者佔45．8％。結論三亞地區DS髮生率較高，提高該地區婦女孕期唐氏篩查及產前診斷率十分必要。
목적：료해삼아지구활산영인당씨종합정（DS）적발생솔，병탐토기상관영향인소。방법장삼아지구주원분면적신생인공25032례납입조사대상，통과외주혈염색체분석대림상의사위DS적환인진행학진。동시수집환인급기쌍친적림상자료，계산해지구DS발생솔，병분석각상관발병인소。결과해지구DS총적발생솔위9．59／만，기중한족위8．34／만，려족위14．42／만；DS환인모친평균육령위29．8세，DS발생솔수모령증장정상승추세。환인모친잉전유독물、약물등“폭로”사자점45．8％。결론삼아지구DS발생솔교고，제고해지구부녀잉기당씨사사급산전진단솔십분필요。
Objective To investigate the incidence of live births with Down syndrome(DS) in Sanya city as well as to discuss the related risk factors .Methods The object of investigation was the 25 032 infants who were born in Sanya city ,then the children with clinical suspected of DS were confirmed by peripheral blood chromosome analysis .Meanwhile ,the clinical data of children and their parents were collected ,calculating the incidence of DS in this region and analyzing the related risk factors .Results In this region , the total incidence of DS was 0 .959‰ ,the incidences in the Han nationality and Li nationality were 0 .834‰ ,1 .442‰ respectively . The mean age of DS children′s mother was 29 .8 years old ,and the incidence of DS increased as their mother grew older .Before pregnancy ,DS children′s mother who had an exposure history of toxicant and drugs accounted for 45 .8% .Conclusion The inci‐dence of DS in Sanya is quite high ,so it is extremely essential to strengthen the women′s pregnancy Down syndrome screening and improve the prenatal diagnosis in this region .
