CAJ | 학술논문

目的：通过卒中后失眠患者脑内神经递质水平、焦虑、抑郁量表的测定，评价口服心脑宁胶囊治疗卒中后失眠的疗效。方法选择108例卒中后失眠患者，随机分为2组：心脑宁胶囊观察组（54例）和艾司唑仑的对照组（54例）。2个疗程后观察2组睡眠质量、精神状态以及脑内神经递质水平的情况。结果观察组总有效率64.8%、对照组68.5%，其差异无统计学意义（P>0.05），但观察组治疗前后脑内5-羟色胺含量提高及γ-氨基丁酸、谷氨酸比值上升，与对照组比较差异有统计学意义（P<0.05，P<0.01），且患者的焦虑量表得分减少12.31分，差异有统计学意义（P<0.01）。结论心脑宁胶囊可行气活血、益气温阳，能有效改善失眠患者脑内神经递质及精神状态。
목적：통과졸중후실면환자뇌내신경체질수평、초필、억욱량표적측정，평개구복심뇌저효낭치료졸중후실면적료효。방법선택108례졸중후실면환자，수궤분위2조：심뇌저효낭관찰조（54례）화애사서륜적대조조（54례）。2개료정후관찰2조수면질량、정신상태이급뇌내신경체질수평적정황。결과관찰조총유효솔64.8%、대조조68.5%，기차이무통계학의의（P>0.05），단관찰조치료전후뇌내5-간색알함량제고급γ-안기정산、곡안산비치상승，여대조조비교차이유통계학의의（P<0.05，P<0.01），차환자적초필량표득분감소12.31분，차이유통계학의의（P<0.01）。결론심뇌저효낭가행기활혈、익기온양，능유효개선실면환자뇌내신경체질급정신상태。
Objective To evaluate the efficacy of Xinnaoning capsule in treating post -stroke insomnia by monitoring the levels of neurotransmitters in the brain and anxiety and depression scales of post-stroke insomnia patients. Methods 108 post-stroke insomnia patients were randomly divided into the treatment group (54 cases), who took Xinnaoning capsules and the control group (54 cases), who took estazolam. Sleep quality and changs of neurotransmitters levels in the brain of the two groups were observed. Results The total effective rate of the treatment group was 64.8% and 68.5% in the control group. There was no significant difference in the efficiency of the two groups (P> 0.05), but anxiety of the treatment group was improved, and the difference (P< 0.05, P< 0.01) in regulating the levels of 5-hydroxytryptamine(3.13 Hz), the ratio of gamma-aminobutyric acid and glutamate(0.6%) and the syndrome of enxiety (12.31) were statistically significant between the two groups. Conclusion Xinnaoning capsule can significantly improve the neurotransmitters and anxiety state of patients by promoting flow of Qi and Blood and warming Yang and invigorating Qi, which can improve the quality of sleep basically.