CAJ | 학술논문

目的：观察自拟消脂汤联合西药治疗男性高脂血症的临床疗效及不良反应。方法选择2010年1月至2013年1月间该院收治的高脂血症患者80例，随机分为两组，即观察组（n＝40）和对照组（n＝40），对照组予以西药阿托伐他汀钙片治疗，观察组在以上基础上加服自拟消脂汤治疗，治疗16周。观察两组患者在治疗8、16周时治疗前后总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL‐C）、低密度脂蛋白胆固醇（LDL‐C）的变化及不良反应情况并检验血清肌酐（Scr）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、肌酸激酶（CK）。结果经过16周的治疗，观察组TC、TG、LDL‐C治疗前分别为（5．87±0．89）、（1．62±0．62）、（3．62±0．55）mmol／L，治疗后分别为（4．59±0．52）、（1．53±0．53）、（2．69±0．41）mmol／L，较服药前差异有统计学意义（P＜0．05）；对照组TC、LDL‐C治疗前分别为（5．88±0．91）、（3．78±0．43）mmol／L，治疗后分别为（5．01±0．49）、（2．97±0．27）mmol／L，差异有统计学意义（P＜0．05），TG在治疗前后差异无统计学意义（P＞0．05）。在降脂幅度方面，观察组在降低TC、LDL‐C方面强于对照组（P＜0．05）。对照组不良反应率较高，两组不良反应率差异有统计学意义（P＜0．05），但均可自行缓解。生活质量评分观察组较对照组显著提高（P＜0．05）。结论自拟消脂汤联合西药对男性高脂血症患者的调脂效果强于单纯西药降脂，且安全性良好，不良反应小。
목적：관찰자의소지탕연합서약치료남성고지혈증적림상료효급불량반응。방법선택2010년1월지2013년1월간해원수치적고지혈증환자80례，수궤분위량조，즉관찰조（n＝40）화대조조（n＝40），대조조여이서약아탁벌타정개편치료，관찰조재이상기출상가복자의소지탕치료，치료16주。관찰량조환자재치료8、16주시치료전후총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL‐C）、저밀도지단백담고순（LDL‐C）적변화급불량반응정황병검험혈청기항（Scr）、곡병전안매（ALT）、곡초전안매（AST）、기산격매（CK）。결과경과16주적치료，관찰조TC、TG、LDL‐C치료전분별위（5．87±0．89）、（1．62±0．62）、（3．62±0．55）mmol／L，치료후분별위（4．59±0．52）、（1．53±0．53）、（2．69±0．41）mmol／L，교복약전차이유통계학의의（P＜0．05）；대조조TC、LDL‐C치료전분별위（5．88±0．91）、（3．78±0．43）mmol／L，치료후분별위（5．01±0．49）、（2．97±0．27）mmol／L，차이유통계학의의（P＜0．05），TG재치료전후차이무통계학의의（P＞0．05）。재강지폭도방면，관찰조재강저TC、LDL‐C방면강우대조조（P＜0．05）。대조조불량반응솔교고，량조불량반응솔차이유통계학의의（P＜0．05），단균가자행완해。생활질량평분관찰조교대조조현저제고（P＜0．05）。결론자의소지탕연합서약대남성고지혈증환자적조지효과강우단순서약강지，차안전성량호，불량반응소。
Objective To observe the clinical effect and side effect of Xiaozhitang combined with western medicine .Methods Eighty male patients with hyperlipidemia in our hospital was selected from January 2010 to January 2013 and divided randomly into observation group(n=40)and control group(n=40) .Patients in the control group received treatment with atorvastatin calcium (10 mg/d)while patients in the observation group were administrated with Xiaozhitang besides the routine measures .The values of total cholesterol (TC) ,triglyceride(TG) ,high density lipoprotein cholesterol(HDL‐C)and low‐density lipoprotein cholesterol(LDL‐C) serum creatinine(Scr) ,alanine transaminase(ALT) ,aspartate aminotransferase(AST) ,creatine kinase(CK)were assessed before and after 8 ,16 weeks treatment .Drug‐induced adverse effects were also observed .Results TC ,TG ,LDL‐C were (5 .87 ± 0 .89) , (1 .62 ± 0 .62) ,(3 .62 ± 0 .55)mmol/L in the observation group before treatment and significantly reduced after 16 weeks treatment [(4 .59 ± 0 .52) ,(1 .53 ± 0 .53) ,(2 .69 ± 0 .41)mmol/L](P<0 .05) .TC ,LDL‐C were(5 .88 ± 0 .91) ,(3 .78 ± 0 .43)mmol/L in the control group before treatment and also significantly reduced after 16 weeks treatment[(5 .01 ± 0 .49) ,(2 .97 ± 0 .27)mmol/L](P<0 .05)while TG remained unchanged during 16 weeks in the control group(P>0 .05) .The observation group achieved a significantly greater reduction in LDL‐C and TC than the control group (P<0 .05) .There was a significantly differences in adverse reaction(P<0 .05)but all could be well tolerated .The quality of life score of the observation group was significantly higher than that of the con‐trol group(P<0 .05) .Conclusion The Xiaozhitang combined with atorvastatin calcium could achieve a significantly greater reduc‐tion in lipid‐lowering effect than pure western medicine ,and it shows satisfactory safety and have less side effect .