CAJ | 학술논문

目的：探讨1‐磷酸鞘氨醇（S1P）及脂联素在冠状动脉支架植入术后的预测价值。方法选择经复查冠脉造影后证实为支架内再狭窄患者50例为再狭窄组，选取同时期支架内无再狭窄者50例为对照组，收集研究对象的临床相关资料，分别检测其血清1‐磷酸鞘氨醇（S1P）、HDL‐S1P、脂联素及IL‐18水平，分析其与支架内再狭窄的相关性。结果与对照组比较，再狭窄组血清总S1P水平更低[（96．10±26．33）ng／mLvs．（113．40±32．72）ng／mL，P＜0．01]，HDL‐S1P水平明显降低[（32．81±10．02）ng／mLvs．（42．72±11．75）ng／mL，P＜0．01]，脂联素水平也明显降低[（7．38±2．11）mg／Lvs．（9．25±3．29）mg／L，P＜0．01]，而两组间IL‐18水平则差异无统计学意义[（258．15±82．19）ng／Lvs．（224．98±84．15）ng／L，P＞0．05]；脂联素与S1P（r＝0．712，P＜0．05）及HDL‐S1P（r＝0．821，P＜0．01）之间均呈正相关。结论S1P及脂联素是冠脉支架内再狭窄的独立预测因素，相对较高的S1P及脂联素浓度能降低经皮冠状动脉介入治疗（PCI）术后患者支架内再狭窄的风险。
목적：탐토1‐린산초안순（S1P）급지련소재관상동맥지가식입술후적예측개치。방법선택경복사관맥조영후증실위지가내재협착환자50례위재협착조，선취동시기지가내무재협착자50례위대조조，수집연구대상적림상상관자료，분별검측기혈청1‐린산초안순（S1P）、HDL‐S1P、지련소급IL‐18수평，분석기여지가내재협착적상관성。결과여대조조비교，재협착조혈청총S1P수평경저[（96．10±26．33）ng／mLvs．（113．40±32．72）ng／mL，P＜0．01]，HDL‐S1P수평명현강저[（32．81±10．02）ng／mLvs．（42．72±11．75）ng／mL，P＜0．01]，지련소수평야명현강저[（7．38±2．11）mg／Lvs．（9．25±3．29）mg／L，P＜0．01]，이량조간IL‐18수평칙차이무통계학의의[（258．15±82．19）ng／Lvs．（224．98±84．15）ng／L，P＞0．05]；지련소여S1P（r＝0．712，P＜0．05）급HDL‐S1P（r＝0．821，P＜0．01）지간균정정상관。결론S1P급지련소시관맥지가내재협착적독립예측인소，상대교고적S1P급지련소농도능강저경피관상동맥개입치료（PCI）술후환자지가내재협착적풍험。
Objective To investigate the predictive value of sphingosine‐1‐phosphate (S1P) and adiponectin after coronary stent implantation .Methods Fifty patients confirmed by coronary angiography with in‐stent restenosis were selected as in‐stent resteno‐sis group while 50 patients without in‐stent restenosis were chose as control group .All cases were detected with the density of their serum S1P ,HDL‐S1P ,adiponectin and IL‐18 and analyzed relevance to in‐stent restenosis .Results Compared with the control group ,serum S1P in in‐stent restenosis group were lower [ (96 .10 ± 26 .33)ng/mL vs .(113 .40 ± 32 .72)ng/mL ,P<0 .01] ,and the levels of HDL‐S1P and adiponectin were also significant lower [(32 .81 ± 10 .02)ng/mL vs .(42 .72 ± 11 .75)ng/mL ,P< 0 .01 ;(7 .38 ± 2 .11)mg/L vs .(9 .25 ± 3 .29)mg/L ,P< 0 .01] .IL‐18 levels between the two groups had no significantly difference [(258 .15 ± 82 .19)ng/L vs .(224 .98 ± 84 .15)ng/L ,P>0 .05] .Adiponectin showed a positive correlation between S1P (r=0 .712 , P<0 .05) and HDL‐S1P (r=0 .821 ,P<0 .01) .Conclusion S1P and adiponectin could be independent predictive factor of coronary stent restenosis ,and high concentrations of S1P and adiponectin may reduce risk of in‐stent restenosis in patients with stenting per‐cutaneous coronary intervention (PCI) .