CAJ | 학술논문

目的：探讨青蒿素对细胞株HepG2细胞增殖的影响。方法采用MTT法检测青蒿素对HepG2细胞作用后的增殖抑制率，流式细胞术检测药物作用HepG2后细胞周期及细胞凋亡的情况。结果80μmol／L的青蒿素对肝癌细胞株HepG2具有增殖抑制作用，其抑制率呈剂量、时间依赖效应，可使HepG2细胞周期阻滞于G0／S期，并诱导肝癌细胞发生凋亡。结论青蒿素能抑制肝癌HepG2细胞增殖。
목적：탐토청호소대세포주HepG2세포증식적영향。방법채용MTT법검측청호소대HepG2세포작용후적증식억제솔，류식세포술검측약물작용HepG2후세포주기급세포조망적정황。결과80μmol／L적청호소대간암세포주HepG2구유증식억제작용，기억제솔정제량、시간의뢰효응，가사HepG2세포주기조체우G0／S기，병유도간암세포발생조망。결론청호소능억제간암HepG2세포증식。
Objective To investigate the effect of artemisinin on the proliferation of human hepatoma cell line HepG‐2 .Methods The inhibition effect of cell proliferation in human hepatocelluar carcinoma cell line HepG2 of artemisinin was detected by MTT test ,and the cell cycle and apoptosis were detected by Flow cytometry .Results Artemisinin at 80 umol/L could effectively inhibi‐ted the proliferation of HepG‐2 cell in a dose‐and time‐dependent manner;the drugs could block cells at G0/S phase ,and induct the HepG‐2 cell apoptosis .Conclusion Artemisinin could effectively inhibit the proliferation of HepG‐2 cell .