CAJ | 학술논문

目的：评估磁共振T2mapping成像技术在基质诱导自体软骨移植（MACT）术后的定量分析价值。方法纳入6例膝关节MACT术后患者（9处软骨损伤），分别在术后3月、6月及12月进行磁共振动态随访检查，测量软骨修复区与正常对照区深浅两个区域及全层T2值，横向比较同一时间点修复区与正常区T2值差异，纵向评估术后3、6、12个月修复区T2值的变化。结果MACT术后3、6月移植区全层T2值显著高于邻近正常软骨（P均<0.05），术后12月修复区全层T2值变化较正常对照区无明显统计学差异（P=0.063）。术后6、12个月修复区浅层软骨T2值显著高于深层（P均<0.05）。术后3、6、12个月修复区深浅层T2值纵向变化均有统计学差异（P均<0.05）。结论 MACT术后磁共振T2mapping成像可作为评估关节软骨修复效果的重要依据。
목적：평고자공진T2mapping성상기술재기질유도자체연골이식（MACT）술후적정량분석개치。방법납입6례슬관절MACT술후환자（9처연골손상），분별재술후3월、6월급12월진행자공진동태수방검사，측량연골수복구여정상대조구심천량개구역급전층T2치，횡향비교동일시간점수복구여정상구T2치차이，종향평고술후3、6、12개월수복구T2치적변화。결과MACT술후3、6월이식구전층T2치현저고우린근정상연골（P균<0.05），술후12월수복구전층T2치변화교정상대조구무명현통계학차이（P=0.063）。술후6、12개월수복구천층연골T2치현저고우심층（P균<0.05）。술후3、6、12개월수복구심천층T2치종향변화균유통계학차이（P균<0.05）。결론 MACT술후자공진T2mapping성상가작위평고관절연골수복효과적중요의거。
Objective To assess the value of magnetic resonance imaging (MRI) T2 mapping in quantitative evaluation of cartilage repair following matrix-associated autologous chondrocyte transplantation (MACT). Methods Six patients (with 9 plug cartilages) following MACT underwent MRI on a 3.0 Tesla MR scan system at 3, 6 and 12 months after the surgery. The full-thickness and zonal areas (deep and superficial layers) T2 values were calculated for the repaired cartilage and control cartilage. Results The mean T2 values of the repaired cartilage after MACT were significantly higher than that of the control cartilages at 3 and 6 months (P<0.05), but not at 12 months (P=0.063). At 6 and 12 months, the T2 values of the superficial layers were significantly higher than those of the deep layers in the repaired cartilages (P<0.05). The zonal (deep and superficial layers) T2 values of the repaired cartilages decreased significantly over time at 6 and 12 months as compared to those at 3 months after the surgery (P<0.05). Conclusion MRI T2 mapping can serve as an important modality for assessing the repair of the articular cartilage following MACT.