西部中医药
西部中醫藥
서부중의약
GANSU JOURNAL OF TRADITIONAL CHINESE MEDICINE
2015年
1期
13-15
,共3页
湿疹皮炎%豚鼠%肤敏膏
濕疹皮炎%豚鼠%膚敏膏
습진피염%돈서%부민고
eczematous dermatitis%guinea pig%FuMincream
目的：研究“肤敏膏”对豚鼠湿疹皮炎模型皮肤组织病理学的影响，探讨其治疗作用及机理。方法：以2，4-二硝基氯苯(DNFB)建立豚鼠湿疹皮炎模型，采用HE常规病理及透射电镜超微病理学检测方法，观察“肤敏”膏对实验性豚鼠湿疹皮炎的治疗作用。结果：“肤敏膏”能改善动物湿疹皮炎模型皮肤组织病变，减少炎性细胞浸润。结论：“肤敏膏”对Th1/Th2细胞平衡失调所引起的后续皮肤炎症反应和组织损伤有明显抑制作用，从而间接调节Th1/Th2细胞动态平衡，改善过敏症状。
目的：研究“膚敏膏”對豚鼠濕疹皮炎模型皮膚組織病理學的影響，探討其治療作用及機理。方法：以2，4-二硝基氯苯(DNFB)建立豚鼠濕疹皮炎模型，採用HE常規病理及透射電鏡超微病理學檢測方法，觀察“膚敏”膏對實驗性豚鼠濕疹皮炎的治療作用。結果：“膚敏膏”能改善動物濕疹皮炎模型皮膚組織病變，減少炎性細胞浸潤。結論：“膚敏膏”對Th1/Th2細胞平衡失調所引起的後續皮膚炎癥反應和組織損傷有明顯抑製作用，從而間接調節Th1/Th2細胞動態平衡，改善過敏癥狀。
목적：연구“부민고”대돈서습진피염모형피부조직병이학적영향，탐토기치료작용급궤리。방법：이2，4-이초기록분(DNFB)건립돈서습진피염모형，채용HE상규병리급투사전경초미병이학검측방법，관찰“부민”고대실험성돈서습진피염적치료작용。결과：“부민고”능개선동물습진피염모형피부조직병변，감소염성세포침윤。결론：“부민고”대Th1/Th2세포평형실조소인기적후속피부염증반응화조직손상유명현억제작용，종이간접조절Th1/Th2세포동태평형，개선과민증상。
Objective: To investigate the influence ofFuMincream on skin pathology of guinea pigs suffering from eczematous dermatitis, explore its therapeutic function and the pathogenesis. Methods: Models were prepared by DNFB, curative effects ofFuMincream on the models were observed by HE staining method and ultrastructural pathological detection of transmission electron microscope. Results: FuMin cream could improve skin pathological changes of the animals with eczematous dermatitis and reduce inflammatory cells infiltration. Conclusion:FuMin cream could inhibit inflammatory reaction and tissue damage significantly induced by the imbalance of TH1/Th2 cells, consequently, regulate dynamic balance of TH1/Th2 cells indirectly and improve allergic symptoms.
