西部中医药
西部中醫藥
서부중의약
GANSU JOURNAL OF TRADITIONAL CHINESE MEDICINE
2015年
1期
7-10
,共4页
李红霞%万国蕊%徐静%刘艳%吕红玉%刘召(指导)
李紅霞%萬國蕊%徐靜%劉豔%呂紅玉%劉召(指導)
리홍하%만국예%서정%류염%려홍옥%류소(지도)
子宫内膜异位症%孕三烯酮%性腺激素%血清炎性细胞因子%三花益肾汤
子宮內膜異位癥%孕三烯酮%性腺激素%血清炎性細胞因子%三花益腎湯
자궁내막이위증%잉삼희동%성선격소%혈청염성세포인자%삼화익신탕
endometriosis%gestrinone%gonadal hormone%serum inflammatory cytokines%SanHuaYiShenTang
目的:观察三花益肾汤治疗子宫内膜异位症(EM)的临床疗效,探讨其作用机理。方法:将EM患者60例随机分为治疗组、对照组各30例,治疗组予三花益肾汤治疗,1剂/d,对照组予孕三烯酮治疗,2.5 mg/次,2次/周,连续治疗3个月后比较2组临床总有效率、主观症状改善情况、子宫体积及盆腔包块变化情况、血清糖链抗原125(CA125)、雌二醇(E2)、催乳素(PRL)、孕酮(P)、血管内皮生长因子(VEGF)、肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)等变化情况。结果:总有效率治疗组为90.0%,对照组为86.7%,2组比较差异无统计学意义(P>0.05);2组患者治疗后CA125、E2、PRL、VEGF、TNF-α、IL-6含量较治疗前明显下降,P水平有所上升;主观症状明显改善;盆腔包块较治疗前缩小,且治疗组较对照组缩小明显(P<0.05),子宫体积大小治疗前后无变化(P>0.05)。结论:三花益肾汤能抑制异位内膜播散种植而消除病灶,缓解疼痛,提高受孕率,减少复发。
目的:觀察三花益腎湯治療子宮內膜異位癥(EM)的臨床療效,探討其作用機理。方法:將EM患者60例隨機分為治療組、對照組各30例,治療組予三花益腎湯治療,1劑/d,對照組予孕三烯酮治療,2.5 mg/次,2次/週,連續治療3箇月後比較2組臨床總有效率、主觀癥狀改善情況、子宮體積及盆腔包塊變化情況、血清糖鏈抗原125(CA125)、雌二醇(E2)、催乳素(PRL)、孕酮(P)、血管內皮生長因子(VEGF)、腫瘤壞死因子(TNF-α)、白細胞介素6(IL-6)等變化情況。結果:總有效率治療組為90.0%,對照組為86.7%,2組比較差異無統計學意義(P>0.05);2組患者治療後CA125、E2、PRL、VEGF、TNF-α、IL-6含量較治療前明顯下降,P水平有所上升;主觀癥狀明顯改善;盆腔包塊較治療前縮小,且治療組較對照組縮小明顯(P<0.05),子宮體積大小治療前後無變化(P>0.05)。結論:三花益腎湯能抑製異位內膜播散種植而消除病竈,緩解疼痛,提高受孕率,減少複髮。
목적:관찰삼화익신탕치료자궁내막이위증(EM)적림상료효,탐토기작용궤리。방법:장EM환자60례수궤분위치료조、대조조각30례,치료조여삼화익신탕치료,1제/d,대조조여잉삼희동치료,2.5 mg/차,2차/주,련속치료3개월후비교2조림상총유효솔、주관증상개선정황、자궁체적급분강포괴변화정황、혈청당련항원125(CA125)、자이순(E2)、최유소(PRL)、잉동(P)、혈관내피생장인자(VEGF)、종류배사인자(TNF-α)、백세포개소6(IL-6)등변화정황。결과:총유효솔치료조위90.0%,대조조위86.7%,2조비교차이무통계학의의(P>0.05);2조환자치료후CA125、E2、PRL、VEGF、TNF-α、IL-6함량교치료전명현하강,P수평유소상승;주관증상명현개선;분강포괴교치료전축소,차치료조교대조조축소명현(P<0.05),자궁체적대소치료전후무변화(P>0.05)。결론:삼화익신탕능억제이위내막파산충식이소제병조,완해동통,제고수잉솔,감소복발。
Objective: To observe clinical effect ofSanHuaYiShenTangin the treatment for endometriosis (EM) and investigate its mechanism. Methods: Sixty endometriosis patients were randomized into the treatment group and the control gorup. The cases of the treatment group were treated withSanHuaYiShendecoction, one dose a day, the patients in the control group were administered with gestrinone, 2.5 mg each time, twice each week, after treating for three consecutive months, total effective rate, the improvements of subjective symptoms, uterine volume and pelvic mass, the changes of serum carbohydrate antigen 125 (CA125), estrogen (E2), prolactin (PRL), progesterone (P), vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-α) and interleukin6 (IL-6) were com-pared in both groups. Results: Total effective rate of the treatment group was 90%, higher than 86.7% of the control group, but the difference had no statistical meaning (P>0.05); the contents of CA125, E2, PRL, VEGF, TNF-αand IL-6 of both groups after treating were decreased compared with before treating significantly, P level was raised; subjective symptoms were improved notably; pelvic mass was reduced compared with before treating, the decrease of the treatment group was more notable compared with the control group (P<0.05), there was no change in uterine volume between before and after treating (P>0.05). Conclusion:SanHuaYiShenTangis effective in eliminating the lesions, relieving the pain, increasing conception rate and reducing the recidivism by inhibiting the dissemination of ectopic endometrium.