CAJ | 학술논문

目的：观察参龟助长颗粒治疗特发性矮小症的临床疗效，探讨参龟助长颗粒治疗矮身材儿童的作用机制。方法：采取分组随机平行对照临床研究方法，将特发性矮小症儿童106例分为治疗组、对照组各53例。观察2组儿童治疗前后临床疗效、促生长及血清免疫球蛋白变化情况。结果：总有效率治疗组为81.13%，与对照组的58.49%比较差异有统计学意义（P＜0.05）；治疗组HtSDS、GV、△PAH、证候总积分、免疫球蛋白治疗前后比较差异有统计学意义（P＜0.05），对照组HtSDS、GV、△PAH、IgA、IgG治疗前后比较差异无统计学意义（P＞0.05），证候总积分、IgM治疗前后比较差异有统计学意义（P＜0.05）；治疗后HtSDS、GV、△PAH治疗组较对照组改善明显（P＜0.05）；证候总积分治疗组改善优于对照组（P＜0.01）。结论：参龟助长颗粒可促进特发性矮小症患儿的生长，增加食欲、体重，提高免疫球蛋白。
목적：관찰삼구조장과립치료특발성왜소증적림상료효，탐토삼구조장과립치료왜신재인동적작용궤제。방법：채취분조수궤평행대조림상연구방법，장특발성왜소증인동106례분위치료조、대조조각53례。관찰2조인동치료전후림상료효、촉생장급혈청면역구단백변화정황。결과：총유효솔치료조위81.13%，여대조조적58.49%비교차이유통계학의의（P＜0.05）；치료조HtSDS、GV、△PAH、증후총적분、면역구단백치료전후비교차이유통계학의의（P＜0.05），대조조HtSDS、GV、△PAH、IgA、IgG치료전후비교차이무통계학의의（P＞0.05），증후총적분、IgM치료전후비교차이유통계학의의（P＜0.05）；치료후HtSDS、GV、△PAH치료조교대조조개선명현（P＜0.05）；증후총적분치료조개선우우대조조（P＜0.01）。결론：삼구조장과립가촉진특발성왜소증환인적생장，증가식욕、체중，제고면역구단백。
Objective: To study therapeutic effect ofShenGuigrowth-promoting granules and explore its mechanism in treating idiopathic short stature. Methods: All 106 children with idiopathic short stature were random-ly divided into the treatment group and the control group by using randomized paralleled controlled method. Cura-tive effects, growth-promoting factors and the changes of serum immunoglobulin of both groups were observed be-tween before and after treating. Results: Total effective rate of the treatment group was 81.13%, the difference had statistical meaning compared with 58.49% of the control group (P<0.05); the comparison between before and after treating had the difference in HtSDS, GV,△PAH, total scales of syndrome with statistical meaning in the treatment group (P<0.05), The difference of HtSDS, GV,△PAH, IgA and IgG had no statistical meaning in the control group (P>0.05), the difference showed statistical meaning in total scales of syndrome and IgM in the comparison between before and after treating (P<0.05); the improvements of HtSDS, GV and△PAH in the treatment group were more obvious than these of the control group(P<0.05); the treatment group was superior to the control group in improving total scales of syndrome (P<0.01). Conclusion:ShenGuigrowth-promoting granules can promote the growth of the children with idiopathic short stature, elevate immunoglobulin level, arouse the appetite and increase their weight.