CAJ | 학술논문

目的：观察肠安康胶囊联合美沙拉嗪治疗溃疡性结肠炎的临床疗效。方法：将溃疡性结肠炎患者60例随机分为2组各30例，对照组使用美沙拉嗪肠溶片治疗，3次/d，0.5 g/次，观察组在对照组治疗的基础上使用肠安康胶囊4.4 g/d，2组均连续治疗1个月后观察治疗前后SOD和GSH-PX变化情况及患者临床症状改善时间，并在治疗后1月实施肠镜检查，观察治疗后肠镜等级。结果：治疗后观察组SOD和GSH-PX均高于对照组(P＜0.05)；观察组腹痛腹胀、便血、里急后重及腹泻改善时间快于对照组(P＜0.05)；观察组肠镜复查等级在Ⅱ级及以下的比例高于对照组(P＜0.05)。结论：肠安康胶囊联合美沙拉嗪治疗溃疡性结肠炎，能有效抑制氧自由基对机体的损伤，缓解患者临床症状，提高治疗效果。
목적：관찰장안강효낭연합미사랍진치료궤양성결장염적림상료효。방법：장궤양성결장염환자60례수궤분위2조각30례，대조조사용미사랍진장용편치료，3차/d，0.5 g/차，관찰조재대조조치료적기출상사용장안강효낭4.4 g/d，2조균련속치료1개월후관찰치료전후SOD화GSH-PX변화정황급환자림상증상개선시간，병재치료후1월실시장경검사，관찰치료후장경등급。결과：치료후관찰조SOD화GSH-PX균고우대조조(P＜0.05)；관찰조복통복창、편혈、리급후중급복사개선시간쾌우대조조(P＜0.05)；관찰조장경복사등급재Ⅱ급급이하적비례고우대조조(P＜0.05)。결론：장안강효낭연합미사랍진치료궤양성결장염，능유효억제양자유기대궤체적손상，완해환자림상증상，제고치료효과。
Objective: To investigate the effect of ChangAnKangCapsule combined with mesalazine on the treatment of ulcerative colitis. Methods: Overall 60 cases with ulcerative colitis were randomly divided into the con-trol group and the observation group with 30 cases respectively. Patients in the control group were given mesalazine enteric-coated tablets, 3 times a day, 0.5g each time; besides taking mesalazine like patients in the control group, pa-tients in the observation group were administered ChangAnKang Capsule 4.4g a day. After one month treatment, the changes of SOD and GSH-PX levels as well as the time the clinical symptoms improved were compared before and after treatment in both groups; meanwhile, the ulcer degrees observed by colonoscopy would be presented in two groups. Results: The levels of SOD and GSH-PX in the observation group were higher than that in the control group (P<0.05); the improved time of symptoms like abdominal pain and distention, hematochezia, tenesmus and diarrhea in the observation group was faster than that in the control group (P<0.05); the ulcer degrees in and belowⅡlevel determined by colonoscopy in the observation group were more than the control group (P<0.05). Conclusion: The integration ofChangAnKangCapsule and mesalazine in treating ulcerative colitis can effectively inhibit the body im-pairment from oxygen free radicals, relieve clinical symptoms and improve the therapeutic effect.