西部中医药
西部中醫藥
서부중의약
GANSU JOURNAL OF TRADITIONAL CHINESE MEDICINE
2015年
1期
66-68
,共3页
原发性硬化性胆管炎%碱性磷酸酶%C反应蛋白%γ谷氨酰转移酶%结合胆红素
原髮性硬化性膽管炎%堿性燐痠酶%C反應蛋白%γ穀氨酰轉移酶%結閤膽紅素
원발성경화성담관염%감성린산매%C반응단백%γ곡안선전이매%결합담홍소
primary sclerosing cholangitis%ALP%CRP%γ-GT%TBIL
目的：探讨疏肝化瘀通络汤对原发性硬化性胆管炎中碱性磷酸酶(ALP)，C反应蛋白(CRP)，γ谷氨酰转移酶(γ-GT)，结合胆红素(TBIL)生化水平的影响。方法：将原发性硬化性胆管炎患者48例随机分为治疗组25例，口服疏肝化瘀通络汤250 mL，2次/d；对照组23例口服熊去氧胆酸[20 mg/(kg·d)]，1次/d；波尼松30 mg，1次/d。2组均在用药前后观察患者症状、体征，检测ALP、CRP、γ-GT、TBIL水平。结果：治疗组治愈19例，好转4例，无效2例，总有效率92.0%；对照组治愈16例，好转3例，无效4例，总有效率82.6%。治疗组临床疗效明显优于对照组，2组患者治疗前ALP、CRP、γ-GT、TBIL比较差异无统计学意义(P＞0.05)。治疗后各指标组内比较差异有统计学意义(P＜0.01)。结论：疏肝化瘀通络汤治疗原发性硬化性胆管炎的疗效明显优于熊去氧胆酸，可能通过抑制ALP、CRP、γ-GT、TDBIL水平，减轻原发性硬化性胆管炎的体征和生化指标来实现。
目的：探討疏肝化瘀通絡湯對原髮性硬化性膽管炎中堿性燐痠酶(ALP)，C反應蛋白(CRP)，γ穀氨酰轉移酶(γ-GT)，結閤膽紅素(TBIL)生化水平的影響。方法：將原髮性硬化性膽管炎患者48例隨機分為治療組25例，口服疏肝化瘀通絡湯250 mL，2次/d；對照組23例口服熊去氧膽痠[20 mg/(kg·d)]，1次/d；波尼鬆30 mg，1次/d。2組均在用藥前後觀察患者癥狀、體徵，檢測ALP、CRP、γ-GT、TBIL水平。結果：治療組治愈19例，好轉4例，無效2例，總有效率92.0%；對照組治愈16例，好轉3例，無效4例，總有效率82.6%。治療組臨床療效明顯優于對照組，2組患者治療前ALP、CRP、γ-GT、TBIL比較差異無統計學意義(P＞0.05)。治療後各指標組內比較差異有統計學意義(P＜0.01)。結論：疏肝化瘀通絡湯治療原髮性硬化性膽管炎的療效明顯優于熊去氧膽痠，可能通過抑製ALP、CRP、γ-GT、TDBIL水平，減輕原髮性硬化性膽管炎的體徵和生化指標來實現。
목적：탐토소간화어통락탕대원발성경화성담관염중감성린산매(ALP)，C반응단백(CRP)，γ곡안선전이매(γ-GT)，결합담홍소(TBIL)생화수평적영향。방법：장원발성경화성담관염환자48례수궤분위치료조25례，구복소간화어통락탕250 mL，2차/d；대조조23례구복웅거양담산[20 mg/(kg·d)]，1차/d；파니송30 mg，1차/d。2조균재용약전후관찰환자증상、체정，검측ALP、CRP、γ-GT、TBIL수평。결과：치료조치유19례，호전4례，무효2례，총유효솔92.0%；대조조치유16례，호전3례，무효4례，총유효솔82.6%。치료조림상료효명현우우대조조，2조환자치료전ALP、CRP、γ-GT、TBIL비교차이무통계학의의(P＞0.05)。치료후각지표조내비교차이유통계학의의(P＜0.01)。결론：소간화어통락탕치료원발성경화성담관염적료효명현우우웅거양담산，가능통과억제ALP、CRP、γ-GT、TDBIL수평，감경원발성경화성담관염적체정화생화지표래실현。
Objective: To explore the influence of Liver-soothing, Stasis-removing and Collateral-dredging Tang over primary sclerosing cholangitis at the biochemical levels as alkaline phosphatase (ALP), c-reactive protein (CRP),γ-glutamyl transferase(γ-GT) and total bilirubin (TBIL). Methods: Overall 48 cases of primary sclerosing cholangitis rabomized into the treatment group orally taken 250ml Liver-soothing, Stasis-removing and Collateral-dredging Tang, twice a day and the control group administered oral ursodeoxycholic acid [20 mg/(kg·d)] and 30mg prednisone, once a day. The symptoms and signs were observed and the levels of ALP, CRP,γ-GT as well as TBIL were detected in both groups after and before treatment. Results: In the treatment group, 4 cases were effective, 19 cases were cured, 2 cases ineffective and the total effective rate was 92.0%, while in the control group, 3 cases were effective, 16 cases were cured, 4 cases ineffective and the total effective rate was 82.6%. The clinical effect of the treatment group was obviously better than that of the control group; the comparison of ALP, CRP,γ-GT and TBIL levels in both groups before treatment had no statistical meaning (P>0.05); after treatment, the differences of indexes in both groups were significant(P<0.01). Conclusion: The effect of Liver-soothing, Stasis-removing and Collateral-dredging Tang is better than ursodeoxycholic acid in treating primary sclerosing cholangitis relevant to its mechanism in inhibiting ALP, CRP,γ-GT and TBIL levels to decrease the symptoms and biochemical indexes of primary sclerosing cholangitis.
