CAJ | 학술논문

承气汤出自仲景《伤寒论》，是治疗阳明腑实证的主方。吴鞠通化裁承气汤，创制了“肺肠同治”的代表方剂宣白承气汤，被广泛用于治疗痰热壅肺、腑气不通等肺系疾病。作者的研究团队开展了多中心随机对照的临床研究，为宣白承气汤治疗慢性阻塞性肺疾病痰热壅肺证提供循证医学证据。在此基础上，系统探讨了宣白承气汤“承顺胃气”以“宣肺”的生物学机制。历经多年的RCT研究证实了宣白承气汤可有效治疗慢性阻塞性肺疾病急性加重痰热壅肺证，创新了COPD中医新治法，提高了临床疗效。宣白承气汤“承顺胃气”以“宣肺”的生物学机制与调节肺组织氧化／抗氧化失衡、黏液高分泌、黏膜免疫、气道重构、炎症反应、神经肽分泌等密切相关。尤其是对神经肽通路的研究，为揭示宣白承气汤“承顺胃气”以“宣肺”的机制及本方临床应用治疗肺系疾病提供了实验依据。
승기탕출자중경《상한론》，시치료양명부실증적주방。오국통화재승기탕，창제료“폐장동치”적대표방제선백승기탕，피엄범용우치료담열옹폐、부기불통등폐계질병。작자적연구단대개전료다중심수궤대조적림상연구，위선백승기탕치료만성조새성폐질병담열옹폐증제공순증의학증거。재차기출상，계통탐토료선백승기탕“승순위기”이“선폐”적생물학궤제。력경다년적RCT연구증실료선백승기탕가유효치료만성조새성폐질병급성가중담열옹폐증，창신료COPD중의신치법，제고료림상료효。선백승기탕“승순위기”이“선폐”적생물학궤제여조절폐조직양화／항양화실형、점액고분비、점막면역、기도중구、염증반응、신경태분비등밀절상관。우기시대신경태통로적연구，위게시선백승기탕“승순위기”이“선폐”적궤제급본방림상응용치료폐계질병제공료실험의거。
Chengqi Decoction from Treatise on Febrile Diseases by Zhang Zhongjing, is the representative formular of yang bright-ness fu-organ syndrome.Wu Jutong developed Chengqi Decoction by creating Xuanbai Chengqi Decoction, which embodied the i-dea of“simultaneous treatment of lung and intestine”, and widely used to treat phlegm heat obstructing lung, fu qi being obstruc-ted, etc.We had carried out multi-centered randomized controlled study, in order to provide laboratory proof of Xuanbai Chengqi Decoction curing chronic obstructive pulmonary disease of phlegm heat obstructing, and brought to light biological mechanism of Xuanbai Chengqi Decoction which smooth stoma qi to disperse lung qi.RCT research had confirmed that Xuanbai Chengqi Decoc-tion is effective for acute exacerbation of chronic obstructive pulmonary disease with phlegm heat syndrome;supplement novel TCM treatment for COPD.The mechanism of dispersing lung qi is associated with regaining oxidant /antioxidant balance, improve mu-cus hypersecretion, airway remodeling, mucosal immune, inflammatory reaction, neuropeptides etc.The finding of neuropeptide pathways in particular has provided laboratory proof of the Chinese formula.