CAJ | 학술논문

目的：通过观察高氧下大鼠肺、肠黏膜细胞因子IL－1β，IL－2、IL－6、TNF－α含量的变化，探讨“肺与大肠相表里”的生物学机制。方法：实验设立正常空气组、高氧组（吸入40％浓度氧），比较2组肺泡灌洗液、肠黏膜灌洗液中IL－1β，IL－2、IL－6、TNF－α的含量。结果：造模5 d后，大鼠肺泡灌洗液和肠黏膜灌洗液中的IL－1β、IL－2、IL－6含量均较正常空气组呈现明显下降（P＜0．05）；大鼠肺泡灌洗液及肠黏膜灌洗液的TNF－α也表现为较正常空气组下降的趋势（P＞0．05）。结论：肺肠之间在黏膜免疫方面具有同步性，这可能是肺与大肠表里关系的重要的生物学基础。
목적：통과관찰고양하대서폐、장점막세포인자IL－1β，IL－2、IL－6、TNF－α함량적변화，탐토“폐여대장상표리”적생물학궤제。방법：실험설립정상공기조、고양조（흡입40％농도양），비교2조폐포관세액、장점막관세액중IL－1β，IL－2、IL－6、TNF－α적함량。결과：조모5 d후，대서폐포관세액화장점막관세액중적IL－1β、IL－2、IL－6함량균교정상공기조정현명현하강（P＜0．05）；대서폐포관세액급장점막관세액적TNF－α야표현위교정상공기조하강적추세（P＞0．05）。결론：폐장지간재점막면역방면구유동보성，저가능시폐여대장표리관계적중요적생물학기출。
Objective:To observe the hyperoxia stimulus to lung and intestinal mucosa of rats and the changes of the content of cy-tokines IL-1beta,IL-2,IL-6,TNF alpha,so as to explore the biological mechanisms of‘Lung and Large Intestine being interior-ex-teriorly related’ .Methods:The experiment set up two groups-normal group and the hyperoxia one-which the oxygen concentration was 40%.The content of IL-1beta,IL-2,IL-6,the TNF alpha of Bronchoalveolar lavage fluid and intestinal mucosa lavage fluid was compared.Results:After 5 days,compared with normal group,IL-1beta,IL-2 and IL-6 levels of both the Bronchoalveolar lavage flu-id and intestinal mucosa lavage fluid dropped significantly (P<0.05),and TNF alpha of both the Bronchoalveolar lavage fluid and Intestinal mucosa lavage fluid showed a trend of decline.Conclusion:Lung and Large Intestine have the synchronicity from the per-spective of mucosal immunity,and it may be the important biological basis for lung and large intestine exterior-interior relationship.