CAJ | 학술논문

目的：观察中药通痹外敷散对弗氏完全佐剂性大鼠急性关节炎的影响，探讨其作用机制。方法：大鼠随机分为模型组及治疗组，分别于右膝关节腔内注弗氏完全佐剂0．1 mL，术前及术后1周、2周、3周分别测定白细胞介素－1β亚型（ IL－1β）、透明质酸（ HA）含量；测量右足趾关节以下部位的容积，计算各组治疗效果。结果：治疗2周后，治疗组IL－1β明显降低、HA含量明显升高，与治疗前及模型组比较有统计学意义（ P＜0．05）。治疗组足肿胀度及消肿时间明显优于模型组（ P＜0．05）。结论：通痹外敷散能有效治疗弗氏完全佐剂性大鼠急性关节炎，其作用可能是通过抑制IL－1β合成、增加HA含量而起到治疗作用。
목적：관찰중약통비외부산대불씨완전좌제성대서급성관절염적영향，탐토기작용궤제。방법：대서수궤분위모형조급치료조，분별우우슬관절강내주불씨완전좌제0．1 mL，술전급술후1주、2주、3주분별측정백세포개소－1β아형（ IL－1β）、투명질산（ HA）함량；측량우족지관절이하부위적용적，계산각조치료효과。결과：치료2주후，치료조IL－1β명현강저、HA함량명현승고，여치료전급모형조비교유통계학의의（ P＜0．05）。치료조족종창도급소종시간명현우우모형조（ P＜0．05）。결론：통비외부산능유효치료불씨완전좌제성대서급성관절염，기작용가능시통과억제IL－1β합성、증가HA함량이기도치료작용。
Objective:To observe effect of Tongbi Application Powder on Freund’s adjuvant knee arthritis in rats and its mecha-nism.Methods:Rats were randomly divided into model group and treatment group, sc.injected Freund’s adjuvant 0.1ml into right knee, then measured interleukin-1 beta (IL-1 β), hyaluronic acid (HA) before surgery,1wk, 2wk, 3wk after surgery;measured volume below the right toe.Results:After wk2 , treatment group had lower IL-1 beta and higher HA levels, significantly different compared with that before treatment and model group ( P<0.05) .The treatment group’s extent of foot swelling and dura-tion was significantly better than that of model group, ( P<0.05) .Conclusion:Tongbi Application Powder is effective for treating Freund’s adjuvant arthritis in rats, the effect may be induced by inhibiting IL-1 βsynthesis and increasing HA level.