CAJ | 학술논문

目的：通过动态监测抗凝血酶Ⅲ（AT-Ⅲ）和 D-二聚体（D-dimer）的水平变化，以评价其在急性心肌梗死（AMI）诊断、治疗及预后判断的应用价值。方法检测160例 AMI患者（将80例成功实施 PCI的 AMI患者为 PCI组；将80例采用药物保守治疗的 AMI患者为药物保守治疗组）及80例健康体检者血浆 AT-Ⅲ、D-dimer水平。结果PCI组和保守治疗组治疗前 AT-Ⅲ、D-dimer水平与健康对照组相比有显著性差异（P＜0．05）；PCI组和保守治疗组在治疗后3 d、7 d、14 d的 AT-Ⅲ、D-dime水平与治疗后12 h相比均有显著性差异（P＜0．05）；PCI组治疗后12 h的D-dime水平与治疗前相比有显著性差异（P＜0．05）。结论通过连续监测 AMI治疗期间的 AT-Ⅲ和 D-dimer水平，有助于指导 AMI的治疗和预后判断，降低PCI治疗后围手术期并发症的风险。
목적：통과동태감측항응혈매Ⅲ（AT-Ⅲ）화 D-이취체（D-dimer）적수평변화，이평개기재급성심기경사（AMI）진단、치료급예후판단적응용개치。방법검측160례 AMI환자（장80례성공실시 PCI적 AMI환자위 PCI조；장80례채용약물보수치료적 AMI환자위약물보수치료조）급80례건강체검자혈장 AT-Ⅲ、D-dimer수평。결과PCI조화보수치료조치료전 AT-Ⅲ、D-dimer수평여건강대조조상비유현저성차이（P＜0．05）；PCI조화보수치료조재치료후3 d、7 d、14 d적 AT-Ⅲ、D-dime수평여치료후12 h상비균유현저성차이（P＜0．05）；PCI조치료후12 h적D-dime수평여치료전상비유현저성차이（P＜0．05）。결론통과련속감측 AMI치료기간적 AT-Ⅲ화 D-dimer수평，유조우지도 AMI적치료화예후판단，강저PCI치료후위수술기병발증적풍험。
Objective Through dynamic monitoring of AT-Ⅲ and D-dimer level changes,to evaluate the AMI in diagnosis,treatment and prognostic value of application.Methods Detection of 160 cases of AMI patients(80 cases of successful implementation of PCI for AMI patients PCI group,80 cases of AMI patients using medicine conservative treatment for drug conservative treatment group)and 80 cases of healthy check-up AT-Ⅲ,D-dimer level.Results AT-Ⅲ,D-dimer level of PCI group and conservative treatment group before treatment compared with healthy controls had significant difference (P<0.05);AT-Ⅲ,D-dime level of PCI group and conservative treatment group after treatment of 3 d,7 d,14 d compared with 12 h after treatment had significant difference (P<0.05);D-dimer levels of PCI group 12 h after treatment compared with before treatment had significant difference(P<0.05).Conclusion Through continu-ous monitoring AMI treatment during the AT-Ⅲ and D-dimer level,to guide the treatment and prognosis of AMI and to reduce the risk of perioperative complications after PCI treatment.