CAJ | 학술논문

目的：探讨异甘草酸镁保护重症胰腺炎肝功能损害的临床效果。方法于确诊当天除常规治疗胰腺炎外，给予100mg异甘草酸镁溶于5％葡萄糖注射液250ml静滴，每日2次，疗程为7天。结果血清丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素在相同时间低于对照组，白蛋白则高于对照组；血清炎性因子tnfα、il-6、il-8较对照组明显下降，抗炎因子il-10则显著升高；c反应蛋白低于对照组。结论早期应用异甘草酸镁可有效干预重症胰腺炎对肝功能的损害，疗效更可靠。
목적：탐토이감초산미보호중증이선염간공능손해적림상효과。방법우학진당천제상규치료이선염외，급여100mg이감초산미용우5％포도당주사액250ml정적，매일2차，료정위7천。결과혈청병안산안기전이매、천동안산안기전이매、총담홍소재상동시간저우대조조，백단백칙고우대조조；혈청염성인자tnfα、il-6、il-8교대조조명현하강，항염인자il-10칙현저승고；c반응단백저우대조조。결론조기응용이감초산미가유효간예중증이선염대간공능적손해，료효경가고。
Objective investigate the clinical effects of severe acute pancreatitis Magnesium isoglycyrrhizinate protection of liver dysfunction. Methods in the diagnosis of the day, in addition to conventional treatment of pancreatitis, put 100 mg of magnesium isoglycyrrhizinate in 5%glucose injection 250ml infusion, 2 times a day,7 days for a course.Results alanine aminotransferase,aspartate aminotransferase and total bilirubin were lower than the control group at the same time, but albumin was higher than that of the control group. Tumornecrosis factor TNF-α, IL-6, IL-8 compared were little than the control group, anti-inlfammatory factor IL-10 much more increased. And C-reactive protein was lower than the control group.Conclusion the early application of magnesium isoglycyrrhizinate can effectively intervene for severe pancreatitis to liver function damage, the efifcacy more reliable.