南昌大学学报（医学版）
南昌大學學報（醫學版）
남창대학학보（의학판）
ACTA ACADEMIAE MEDICINAE JIANGXI
2014年
12期
56-58
,共3页
罗哌卡因%地佐辛%超前镇痛%白介素-1
囉哌卡因%地佐辛%超前鎮痛%白介素-1
라고잡인%지좌신%초전진통%백개소-1
ropivacaine%dezocine%preemptive analgesia%interleukin-1
目的：研究罗哌卡因和地佐辛超前镇痛对术后疼痛及IL-1的影响。方法选取胆囊结石行腹腔镜胆囊切除术患者20例，按随机数字表法分为罗哌卡因和地佐辛超前镇痛组（L组）和对照组（C组），每组10例。L组麻醉诱导前20min硬膜外腔分次注入含0．25％甲磺酸罗哌卡因4mL、静脉注射地佐辛5mg，关闭腹膜时硬膜外腔给予生理盐水10mL；C组麻醉诱导前20min硬膜外腔给予生理盐水10mL，关闭腹膜时硬膜外腔注入含0．25％甲磺酸罗哌卡因4mL、静脉注射地佐辛5mg。结果静息时VAS评分术后24、48、72hL组均显著低于C组（P＜0．05），咳嗽时VAS评分术后48、72hL组均显著低于C组（P＜0．05），术后血浆IL-1水平L组明显低于C组（P＜0．05）。结论罗哌卡因和地佐辛超前镇痛能明显减轻患者手术后的疼痛和减少炎症介质IL-1的表达。
目的：研究囉哌卡因和地佐辛超前鎮痛對術後疼痛及IL-1的影響。方法選取膽囊結石行腹腔鏡膽囊切除術患者20例，按隨機數字錶法分為囉哌卡因和地佐辛超前鎮痛組（L組）和對照組（C組），每組10例。L組痳醉誘導前20min硬膜外腔分次註入含0．25％甲磺痠囉哌卡因4mL、靜脈註射地佐辛5mg，關閉腹膜時硬膜外腔給予生理鹽水10mL；C組痳醉誘導前20min硬膜外腔給予生理鹽水10mL，關閉腹膜時硬膜外腔註入含0．25％甲磺痠囉哌卡因4mL、靜脈註射地佐辛5mg。結果靜息時VAS評分術後24、48、72hL組均顯著低于C組（P＜0．05），咳嗽時VAS評分術後48、72hL組均顯著低于C組（P＜0．05），術後血漿IL-1水平L組明顯低于C組（P＜0．05）。結論囉哌卡因和地佐辛超前鎮痛能明顯減輕患者手術後的疼痛和減少炎癥介質IL-1的錶達。
목적：연구라고잡인화지좌신초전진통대술후동통급IL-1적영향。방법선취담낭결석행복강경담낭절제술환자20례，안수궤수자표법분위라고잡인화지좌신초전진통조（L조）화대조조（C조），매조10례。L조마취유도전20min경막외강분차주입함0．25％갑광산라고잡인4mL、정맥주사지좌신5mg，관폐복막시경막외강급여생리염수10mL；C조마취유도전20min경막외강급여생리염수10mL，관폐복막시경막외강주입함0．25％갑광산라고잡인4mL、정맥주사지좌신5mg。결과정식시VAS평분술후24、48、72hL조균현저저우C조（P＜0．05），해수시VAS평분술후48、72hL조균현저저우C조（P＜0．05），술후혈장IL-1수평L조명현저우C조（P＜0．05）。결론라고잡인화지좌신초전진통능명현감경환자수술후적동통화감소염증개질IL-1적표체。
Objective To explore the influence of preemptive analgesia with ropivacaine and dezocine on postoperative pain and interleukin-1(IL-1)level.Methods Twenty patients sched-uled for laparoscopic cholecystectomy for cholecystolithiasis were randomly divided into two groups,with 10 patients in each group.The preemptive analgesia group(group L)was given epi-dural injection of 0.25% ropivacaine mesylate(4 mL)and intravenous injection of dezocine(5 mg) 20 minutes before anesthesia induction and epidural injection of normal saline(10 mL)at the time of peritoneal closure.The control group(group C)was given epidural injection of normal saline (10 mL)20 minutes before anesthesia induction and epidural injection of 0.25% ropivacaine me-sylate(4 mL)and intravenous injection of dezocine(5 mg)at the time of peritoneal closure.Results Compared with group C,VAS scores at rest at 24,48 and 72 hours after operation,VAS scores af-ter coughing at 48 and 72 hours after operation,and plasma IL-1 level after operation significantly decreased in group L(P <0.05).Conclusion Preemptive analgesia with ropivacaine and dezocine can alleviate the postoperative pain and decrease the expression of inflammatory mediator IL-1.
