CAJ | 학술논문

目的：分析并发神经精神性狼疮（NPSLE）的儿童狼疮性肾炎（LN）患者的临床特点。方法：对122例首次诊断为 NPSLE 合并 LN 的住院患者进行回顾性研究，收集其临床资料，比较儿童起病组（n＝34）与成年起病组（n＝88）的临床特点，包括：性别、系统性红斑狼疮（SLE）的病程、临床表现、实验室检查等。结果：儿童起病组SLE 病程较成年起病组短（P ＜0．05）；儿童起病组NPSLE 以痫性发作为主（70．6％），而成年起病组以精神症状为主（52．3％），两组间存在显著性差异。成年起病组发生白细胞减少的比例明显高于儿童起病组（P ＜0．05）。结论：儿童起病的 NPSLE 合并 LN 患者的 SLE 病程、NPSLE 临床类型、发生白细胞减少的比例与成年起病者不同，对不同年龄起病的NPSLE 合并LN 患者应给予不同的治疗策略。
목적：분석병발신경정신성랑창（NPSLE）적인동랑창성신염（LN）환자적림상특점。방법：대122례수차진단위 NPSLE 합병 LN 적주원환자진행회고성연구，수집기림상자료，비교인동기병조（n＝34）여성년기병조（n＝88）적림상특점，포괄：성별、계통성홍반랑창（SLE）적병정、림상표현、실험실검사등。결과：인동기병조SLE 병정교성년기병조단（P ＜0．05）；인동기병조NPSLE 이간성발작위주（70．6％），이성년기병조이정신증상위주（52．3％），량조간존재현저성차이。성년기병조발생백세포감소적비례명현고우인동기병조（P ＜0．05）。결론：인동기병적 NPSLE 합병 LN 환자적 SLE 병정、NPSLE 림상류형、발생백세포감소적비례여성년기병자불동，대불동년령기병적NPSLE 합병LN 환자응급여불동적치료책략。
Objective:To elevate clinical features of childhood-onset patients with neuropsychiatric systemic lupus erythematosus (NPSLE) and nephritis lupus (LN). Methods:Medical records of 122 resident patients diagnosed as NPSLE with LN for the first time were reviewed and classified into two groups according to their ages at disease presentation. Among the patients studied, 34 were childhood onset, 88 were adult onset. We then examined clinical features such as gender, duration of systemic lupus erythematosus (SLE), clinical manifestations and laboratory tests. Results: The study revealed significantly shorter duration of SLE (P < 0.05), higher rates of seizure (70.6% VS. 34.1%, P < 0.05), lower incidence of psychosis (23.5% VS. 52.3%,P < 0.05) and leucopenia (14.7% VS. 35.2%, P < 0.05) in childhood-onset patients. Conclusions: Age at onset has an impact on NPSLE with LN disease status , such as duration of SLE , NPSLE manifestations and leucopenia , and should be considered in the treatment strategies for patients with neuropsychiatric SLE and nephritis lupus.