CAJ | 학술논문

目的：研究地佐辛在局麻玻璃体切除术的临床应用。方法80例择期玻璃体切除术患者， ASAⅠ~Ⅱ级，随机分为实验组（n=40）和对照组（对照组n=40），实验组患者术前缓慢静脉注射地佐辛10 ug/kg。对照组注射相同容量的生理盐水。两组患者均在局部麻醉下将玻璃体的切除术完成。分别记录两组麻醉前(T0)、开始手术（T1）、手术半个小时（T2）和结束手术（T3）后患者心率、脉压、呼吸频率和脉搏的血氧饱和度情况，实施镇静与镇痛评分，记录患者的不良反应情况。结果在T1、T2、T3时点，实验组的HR、RR、MAP及疼痛VAS评分情况比对照组低，镇静Ramsay评分则比对照组高（P＜0.05）差异具有统计学意义；各个时点实验组和对照组的SPO2差异均无统计学意义（P＞0.05）。与对照组比较，实验组患者在麻醉手术中发生恶心、呕吐及呼吸抑制等副反应情况差异无统计学意义（P＞0.05）。结论应用地佐辛能够有效的减轻局部麻醉下患者实施玻璃体切除术的术中疼痛感，稳定血流动力学的波动，具有相应的镇静与镇痛效果，并且不会抑制患者的呼吸，具有重要的临床应用价值。
목적：연구지좌신재국마파리체절제술적림상응용。방법80례택기파리체절제술환자， ASAⅠ~Ⅱ급，수궤분위실험조（n=40）화대조조（대조조n=40），실험조환자술전완만정맥주사지좌신10 ug/kg。대조조주사상동용량적생리염수。량조환자균재국부마취하장파리체적절제술완성。분별기록량조마취전(T0)、개시수술（T1）、수술반개소시（T2）화결속수술（T3）후환자심솔、맥압、호흡빈솔화맥박적혈양포화도정황，실시진정여진통평분，기록환자적불량반응정황。결과재T1、T2、T3시점，실험조적HR、RR、MAP급동통VAS평분정황비대조조저，진정Ramsay평분칙비대조조고（P＜0.05）차이구유통계학의의；각개시점실험조화대조조적SPO2차이균무통계학의의（P＞0.05）。여대조조비교，실험조환자재마취수술중발생악심、구토급호흡억제등부반응정황차이무통계학의의（P＞0.05）。결론응용지좌신능구유효적감경국부마취하환자실시파리체절제술적술중동통감，은정혈류동역학적파동，구유상응적진정여진통효과，병차불회억제환자적호흡，구유중요적림상응용개치。
Objective To study Dezocine vitrectomy in anesthesia clinical application. Methods 80 cases of patients undergoing vitrectomy, ASAⅠ~Ⅱ, were randomly divided into experimental group (n=40) and control group (control group, n=40), patients in the experimental group preoperative slow intravenous injection Dezocine 10ug/kg . The control group was injected with the same volume of saline. All patients were under local anesthesia vitreous surgery is completed. Both groups were recorded before anesthesia (T0), begin surgery (T1), half an hour surgery (T2) and the end of surgery (T3) after the patient's heart rate, pulse, respiratory rate and pulse oximetry, the implementation of the calm and pain scores recorded adverse reactions in patients. Results In T1, T2, T3 point, HR experimental group, RR, MAP and pain VAS scores lower than the control group situation, Ramsay sedation score is higher than the control group (P<0.05);each point in the experimental group and the control SPO2 group no signiifcant difference (P>0.05). The comparison with the control group, the side effects of nausea, vomiting and respiratory depression occurred in the experimental group were no signiifcant differences in anesthesia (P>0.05). Conclusion Dezocine technique can effectively reduce the patient under local anesthesia in the implementation of vitrectomy pain, stable hemodynamic lfuctuations, with a corresponding sedative and analgesic effects, and does not inhibit the patient's breathing, have important clinical value.