EEFSEC基因、染色体17 q24和染色体11 q13．2基因变异与前列腺癌的关联研究
EEFSEC기인、염색체17 q24화염색체11 q13．2기인변이여전렬선암적관련연구
A correlation study between EEFSEC gene, chromosome 17q24, chromosome 11q13.2 and prostate cancer(
  • 万方数据
    中国老年保健医学 중국노년보건의학
    CHINESE JOURNAL OF GERIATRIC CARE
    2015年 1期 5-8,9 ,共5页

    李星慧%张政%张毓洪%王建业%魏东%张耀光%杨泽

    리성혜%장정%장육홍%왕건업%위동%장요광%양택

    前列腺癌%患病风险%基因多态性%临床表型 前列腺癌%患病風險%基因多態性%臨床錶型
    전렬선암%환병풍험%기인다태성%림상표형
    Prostate cancer%risk%clinical phenotype%Single nucleotide polymorphism
    目的：探索EEFSEC基因（rs10934853，A）、染色体17q24区（rs1859962，T）和染色体11q13．2（rs7931342，T）的基因变异类型与前列腺癌患病发病风险的关联，分析这些基因型与前列腺癌患者临床特征的关系。方法采用病例对照研究设计，比较病例组中124例患者和对照组中138例正常对照者的 EEFSEC 基因（ rs10934853， A）、染色体17q24区（rs1859962，T）和染色体11q13．2（rs7931342，T）等位基因和基因型频率的差异，并探讨各基因变异与患者的确诊年龄， BMI，Gleason评分，PSA浓度，肿瘤分期等临床特征之间的关联。结果 EEFSEC 基因（rs10934853，A）、染色体17q24区（rs1859962，T）和染色体11q13．2（rs7931342，T）的基因型和等位基因在病例组和对照组中的频率分布差异均无统计学意义（P＞0．05），然而，EEFSEC基因（rs10934853，A）和染色体17q24区（rs1859962，T）存在更强的基因－基因协同的交互作用（P＝0．0396，OR＝1．722，95％CI＝1．0244～2．8944）；病例组基因型－表型观察指标关联分析表明，3个SNPs与PCa患者的年龄、Gleason评分、PSA浓度及烟酒均无关联（P＞0．05），然而，染色体17q24区（rs1859962，T）位点与食用蛋类有关（P＝0．005）。结论 EEFSEC基因（rs10934853，A），17q24（rs1859962，T）和11q13．2（rs7931342，T）位点可能与我国北方人群前列腺癌的发病风险无关联，但是存在有基因之间增加PCa发病风险的协同效应。
    목적：탐색EEFSEC기인（rs10934853，A）、염색체17q24구（rs1859962，T）화염색체11q13．2（rs7931342，T）적기인변이류형여전렬선암환병발병풍험적관련，분석저사기인형여전렬선암환자림상특정적관계。방법채용병례대조연구설계，비교병례조중124례환자화대조조중138례정상대조자적 EEFSEC 기인（ rs10934853， A）、염색체17q24구（rs1859962，T）화염색체11q13．2（rs7931342，T）등위기인화기인형빈솔적차이，병탐토각기인변이여환자적학진년령， BMI，Gleason평분，PSA농도，종류분기등림상특정지간적관련。결과 EEFSEC 기인（rs10934853，A）、염색체17q24구（rs1859962，T）화염색체11q13．2（rs7931342，T）적기인형화등위기인재병례조화대조조중적빈솔분포차이균무통계학의의（P＞0．05），연이，EEFSEC기인（rs10934853，A）화염색체17q24구（rs1859962，T）존재경강적기인－기인협동적교호작용（P＝0．0396，OR＝1．722，95％CI＝1．0244～2．8944）；병례조기인형－표형관찰지표관련분석표명，3개SNPs여PCa환자적년령、Gleason평분、PSA농도급연주균무관련（P＞0．05），연이，염색체17q24구（rs1859962，T）위점여식용단류유관（P＝0．005）。결론 EEFSEC기인（rs10934853，A），17q24（rs1859962，T）화11q13．2（rs7931342，T）위점가능여아국북방인군전렬선암적발병풍험무관련，단시존재유기인지간증가PCa발병풍험적협동효응。
    Objectives To explore the association between the variations of EEFSEC gene ( rs10934853, A), chromosome 17q24(rs1859962,T) and chromosome 11q13.2 (rs7931342,T) and prostate cancer (Pca) risk in Chinese population in Beijing , and to understand the relationship between genotypes and phenotypes including clinical characteristics and life style , etc.in patients with prostate cancer .Methods Based on a case-control study , 124 patients with prostate cancer and 138 age-matched control sub-jects were recruited.Information of clinical phenotype and life style , etc.in the prostate cancer patients was collected .We com-pared the differences of allele and genotype frequencies of EEFSEC gene (rs10934853, A), chromosome 17q24(rs1859962,T) and chromosome 11q13.2 (rs7931342,T) between the two groups and explored the relationship between different genotypes and clinical features such as age , BMI, Gleason score, PSA level and tumor stage , by Fisher’s exact test and Chi-square test in patients with PCa.Multifactor dimensionality reduction was used to detect the gene-gene interactions .Results There was no obverse distribution of difference in those three SNPS ’ allele or genotype frequency or three kinds of haplotype that composed of EEFSEC gene (rs10934853, A), chromosome 17q24(rs1859962,T) and chromosome 11q13.2 (rs7931342,T) between case and control groups (P>0.05).Analysis showed that chromosome 17q24(rs1859962,T) genotype frequency distribution was correlated eating eggs (P=0.005).Conclusions There is no obvious association of EEFSEC gene (rs10934853, A), chromosome 17q24(rs1859962,T) and chromosome 11q13.2 (rs7931342,T) with PCa in our sample.They may not be genetic risk factors of PCa in Beijing Chinese population.
    원문보기 원문다운로드 사이트로이동
저자의 최근 논문