CAJ | 학술논문

目的：通过Meta分析对紫杉醇＋顺铂（ TP）与吉西他滨＋顺铂（ GP）化疗方案对肺癌抗肿瘤药物治疗患者骨髓抑制的影响进行系统分析，探讨TP和GP的骨髓抑制差别。方法通过荟萃分析对TP与GP的骨髓抑制研究进行同质性检验和合并效应量的估计。结果同质性检验：χ2＝91．84，自由度为29，P＜0．00001；合并效应量的估计：OR合并＝1．36，OR合并95％可信限为0．90～2．04。 OR合并的检验Z＝1．482．41，P＝0．14。结论 TP与GP化疗时对患者的骨髓抑制不良反应情况没有本质区别。
목적：통과Meta분석대자삼순＋순박（ TP）여길서타빈＋순박（ GP）화료방안대폐암항종류약물치료환자골수억제적영향진행계통분석，탐토TP화GP적골수억제차별。방법통과회췌분석대TP여GP적골수억제연구진행동질성검험화합병효응량적고계。결과동질성검험：χ2＝91．84，자유도위29，P＜0．00001；합병효응량적고계：OR합병＝1．36，OR합병95％가신한위0．90～2．04。 OR합병적검험Z＝1．482．41，P＝0．14。결론 TP여GP화료시대환자적골수억제불량반응정황몰유본질구별。
Objectives To compare arrest of bone marrow on different chemo-treatment methods for lung cancer by systems anal-ysis,then investigate which method is the best .Methods The arrest of bone marrow of versus were meta-analyzed using homogeneity test and combined effect test .Results Homogeneity test showed that the cited studies were homogeneous with χ2 =91.84, df=29 and P<0.00001;and by combined test , the combined OR was 1.36(95%confidence interval =0.90~2.04, Z=1.482.41,P=0.14.Conclusions There is no difference between paclitaxel combined with cisplatin and gemzar combined with cisplatin essential -ly.