CAJ | 학술논문

目的：探讨北五味子醇提物（ SCE）对东莨菪碱致小鼠记忆获得障碍的影响。方法将小鼠随机分为空白组、模型组、SCE组（低、中、高剂量组）和阳性药对照组（吡拉西坦），分别灌胃给药之后造模并进行跳台测试；应用分光光度法测定SCE对东莨菪碱所致记忆获得障碍模型小鼠血清和脑组织中乙酰胆碱脂酶（ AChE）活性的影响。结果 SCE组小鼠学习记忆成绩较模型组有显著提高；降低东莨菪碱所致记忆获得障碍模型小鼠血清和脑组织中乙酰胆碱脂酶（ AChE ）的含量。结论 SCE对东莨菪碱造成的记忆获得障碍小鼠的学习记忆能力有明显的改善作用。
목적：탐토북오미자순제물（ SCE）대동랑탕감치소서기억획득장애적영향。방법장소서수궤분위공백조、모형조、SCE조（저、중、고제량조）화양성약대조조（필랍서탄），분별관위급약지후조모병진행도태측시；응용분광광도법측정SCE대동랑탕감소치기억획득장애모형소서혈청화뇌조직중을선담감지매（ AChE）활성적영향。결과 SCE조소서학습기억성적교모형조유현저제고；강저동랑탕감소치기억획득장애모형소서혈청화뇌조직중을선담감지매（ AChE ）적함량。결론 SCE대동랑탕감조성적기억획득장애소서적학습기억능력유명현적개선작용。
Objectives To observe the effects of Schisandra Chinensis Baill Extract (SCE) on acquired learning and memory dis-order of mice.Methods Mice were randomly divided into six groups:normal concrol , model concrol , piracetam and schisandra chinensis baill extract at small ,middle,and high doses.Step-down test was used to observe effects of SCE on acquired learning and memory disorder induced by scopolamine in mice , Spectrophometry was used to measure effects of SCE on acetycholinesterase ( AChE) activities in serum and brain of mice with acquired learning and memory disorder induced by scopolamine .Results SCE would significantly improve the learning and memory abilities of mice ,reduce AChE activities in the brain and serum of mice with ac-quired learning and memory disorder induced by scopolamine .Conclusions SCE would improve the learning and memory abilities of mice induced by scopolamine .