CAJ | 학술논문

目的：探讨福建沿海地区人群心血管活性肽apelin水平与血压的关系。 　　方法：采用横断面调查方法纳入福建沿海地区30~79岁人群1031人，男性416例，平均年龄（55.1±10.9）岁，均行问卷调查、体格检查、血生化及血浆apelin水平检测。1031人根据美国最新高血压治疗指南（JNC7）的高血压定义分组：高血压组（n=496）,收缩压≥140 mmHg（1 mmHg=0.133 kPa）或舒张压≥90 mmHg或已开始服降压药者；正常高值血压组（n=314）：未服用降压药物收缩压120~139 mmHg和（或）舒张压80~89 mmHg；正常血压组（n=221）：未服用降压药物收缩压<120 mmHg且舒张压<80 mmHg。1031人根据apelin四分位水平分为四组，Q1组（n=258）：<164.8ng/ml，Q2组（n=258）：164.8~<220.0 ng/ml，Q3组（n=258）：220.0~283.1 ng/ml，Q4组（n=257）：>283.1 ng/ml。采用单因素方差分析趋势检验、协方差分析和多元线性回归分析评价血浆apelin与血压的相关性。 　　结果：1031人中男性血浆apelin水平[（220.57±78.87）pg/ml]比女性[（232.06±81.17）pg/ml]降低，正常高值血压组与正常血压组比较、高血压组与正常血压组和正常高值血压组比较，apelin水平均降低（P<0.05）。Q2、Q3组与Q1组比较，收缩压、舒张压与平均动脉压均降低, Q4组与其他三组比较，收缩压、舒张压（不包括Q2组和Q3组）与平均动脉压均降低，差异均有统计学意义（P均<0.05）。调整了性别和年龄，收缩压、舒张压及平均动脉压在apelin四分位组间的差异仍有统计学意义（P<0.05）。多元线性回归分析提示收缩压、舒张压及平均动脉压与apelin水平存在负相关，在调整了其它心血管危险因素后，这种相关关系仍然存在。 　　结论：apelin水平随着血压水平的升高而降低，提示心血管活性肽apelin水平与血压调控相关。
목적：탐토복건연해지구인군심혈관활성태apelin수평여혈압적관계。 　　방법：채용횡단면조사방법납입복건연해지구30~79세인군1031인，남성416례，평균년령（55.1±10.9）세，균행문권조사、체격검사、혈생화급혈장apelin수평검측。1031인근거미국최신고혈압치료지남（JNC7）적고혈압정의분조：고혈압조（n=496）,수축압≥140 mmHg（1 mmHg=0.133 kPa）혹서장압≥90 mmHg혹이개시복강압약자；정상고치혈압조（n=314）：미복용강압약물수축압120~139 mmHg화（혹）서장압80~89 mmHg；정상혈압조（n=221）：미복용강압약물수축압<120 mmHg차서장압<80 mmHg。1031인근거apelin사분위수평분위사조，Q1조（n=258）：<164.8ng/ml，Q2조（n=258）：164.8~<220.0 ng/ml，Q3조（n=258）：220.0~283.1 ng/ml，Q4조（n=257）：>283.1 ng/ml。채용단인소방차분석추세검험、협방차분석화다원선성회귀분석평개혈장apelin여혈압적상관성。 　　결과：1031인중남성혈장apelin수평[（220.57±78.87）pg/ml]비녀성[（232.06±81.17）pg/ml]강저，정상고치혈압조여정상혈압조비교、고혈압조여정상혈압조화정상고치혈압조비교，apelin수평균강저（P<0.05）。Q2、Q3조여Q1조비교，수축압、서장압여평균동맥압균강저, Q4조여기타삼조비교，수축압、서장압（불포괄Q2조화Q3조）여평균동맥압균강저，차이균유통계학의의（P균<0.05）。조정료성별화년령，수축압、서장압급평균동맥압재apelin사분위조간적차이잉유통계학의의（P<0.05）。다원선성회귀분석제시수축압、서장압급평균동맥압여apelin수평존재부상관，재조정료기타심혈관위험인소후，저충상관관계잉연존재。 　　결론：apelin수평수착혈압수평적승고이강저，제시심혈관활성태apelin수평여혈압조공상관。
Objectives: To explore the relationship between vascular active peptide, apelin level and blood pressure in a coastal population of Fujian province. Methods: A total of 1031 subjects with the mean age of (55.1 ± 10.9) years in a coastal area of Fujian province were included in this cross-sectional study, and 416 subjects with male gender. The questionnaire survey, physical examination and plasma level of apelin measurement were conducted. Based on JNC-7 deifnition of hypertension, the subjects were divided into 3 groups: ① Hypertension group, the patients with systolic blood pressure (SBP)≥140 mmHg and/or diastolic blood pressure (DBP)≥90 mmHg, n=496. ② Pre-hypertension group, SBP at (120-139) mmHg and/or DBP at (80-89) mmHg without medication, n=314.③Normal BP group, SBP<120mmHg and DBP<80mmHg without medication, n=221. Based on 4 quartiles of apelin levels, the subjects were further divided into 4 groups:Q1 group, apelin<164.8 ng/ml, n=258. Q2 group, apelin at (164.8-<220.0) ng/ml, n=258. Q3 group, apelin at (220.0-283.1) ng/ml, n=258. Q4 group, apelin>283.1 ng/ml, n=257. One way analysis of variance, covariance analysis and multivariate linear regression analysis were used to study the relationship between apelin level and BP. Results: The apelin level in male gender (220.57 ± 78.87) pg/ml was lower than female gender (232.06 ± 81.17) pg/ml. Compared with Normal group, Pre-hypertension group had decreased apelin level, compared with Normal and Pre-hypertension groups, Hypertension group had decreased apelin level, P<0.05. Compared with Q1 group, Q2, Q3 groups presented decreased SBP, DBP and mean arterial blood pressure (MABP), and compared with other 3 groups, Q4 group had decreased SBP, DBP (not including Q2, Q3 groups) and MABP, P<0.05. With adjusted age and gender, SBP, DBP and MABP were signiifcantly different among 4 quartiles of apelin groups, P<0.05. Multivariate linear regression analysis indicated that SBP, DBP and MABP were negatively related to apelin level, such relationship remained the same after adjusting the other cardiovascular risk factors. Conclusion: Apelin level dropping accompanying with BP increasing implies that vascular active peptide, apelin involved in BP regulation.