CAJ | 학술논문

随着细胞组织工程学的发展，骨形态发生蛋白（bone morphogenetic protein，BMP）越来越多的应用在骨科领域，而骨形态发生蛋白-2（bone morphogenetic protein，BMP-2）在治疗骨缺损，骨不愈合等方面的效果已经在基础实验和临床实践上均得到了证实[1-3]，其作用机制可能是BMP-2可诱导间充质干细胞向软骨方向分化，并通过Smad通路及MAPK通路传导，并对骨组织的形成、生长和损伤的修复具有促进作用[4]。基于这一作用机制，越来越多的学者把研究重点放在治疗股骨头坏死领域，文章就近年来BMP-2治疗股骨头坏死研究进展。
수착세포조직공정학적발전，골형태발생단백（bone morphogenetic protein，BMP）월래월다적응용재골과영역，이골형태발생단백-2（bone morphogenetic protein，BMP-2）재치료골결손，골불유합등방면적효과이경재기출실험화림상실천상균득도료증실[1-3]，기작용궤제가능시BMP-2가유도간충질간세포향연골방향분화，병통과Smad통로급MAPK통로전도，병대골조직적형성、생장화손상적수복구유촉진작용[4]。기우저일작용궤제，월래월다적학자파연구중점방재치료고골두배사영역，문장취근년래BMP-2치료고골두배사연구진전。
With the development of tissue engineering, bone morphogenetic protein (bone morphogenetic protein, BMP) applications study is becoming more and more widely in the field of orthopedics,The therapeutic effect of bone morphogenetic protein-2 (bone morphogenetic protein, BMP-2) including bone defects,nonunion and other aspects have been demonstrated on the basis of experimental and clinical practice[1-3],Its mechanism may be BMP-2 can induce differentiation of mesenchymal stem cells into cartilage direction,conduct through Smad pathway and MAPK pathway,and promote bone formation , tissue growth and damage repair[4]. Based on this mechanism of action, more and more scholars have putted study focuses on the field of femoral head necrosis treatment, this article makes a brief summary of the treatment of femoral head necrosis advances of BMP-2 in recent years.