中国骨与关节外科
中國骨與關節外科
중국골여관절외과
CHINESE BONE AND JOINT SURGERY
2014年
6期
472-474
,共3页
腰椎间盘突出%血清%疼痛物质%炎性应激
腰椎間盤突齣%血清%疼痛物質%炎性應激
요추간반돌출%혈청%동통물질%염성응격
Lumbar disc protrusion%Serum,Pain substances%Inflammatory stress
背景：腰椎间盘突出是临床较为常见的疾病，多数患者有不同程度的疼痛表现，严重影响生活质量。目的：探讨腰椎间盘突出患者血清疼痛物质及炎性应激指标的变化。<br> 方法：收集2012年7月至2014年5月收治的88例腰椎间盘突出患者（观察组）和同期进行健康体检的88例志愿者（对照组）的外周静脉血。采用酶联免疫法检测两组的血清疼痛物质（P物质、神经肽Y、神经生长因子）及炎性应激指标（白细胞介素-1β、白细胞介素-6、白细胞介素-8、白细胞介素-10、降钙素原、超敏热休克蛋白、肿瘤坏死因子-α、干扰素-γ）水平并进行比较，同时比较观察组中不同PPI分级者的检测水平。<br> 结果：观察组的血清疼痛物质及炎性应激指标水平均显著高于对照组，且观察组中PPI分级较高者的检测水平高于PPI分级较低者（P＜0.05）。<br> 结论：腰椎间盘突出患者血清疼痛物质及炎性应激指标均呈高表达状态，且受疼痛程度的影响较大。
揹景：腰椎間盤突齣是臨床較為常見的疾病，多數患者有不同程度的疼痛錶現，嚴重影響生活質量。目的：探討腰椎間盤突齣患者血清疼痛物質及炎性應激指標的變化。<br> 方法：收集2012年7月至2014年5月收治的88例腰椎間盤突齣患者（觀察組）和同期進行健康體檢的88例誌願者（對照組）的外週靜脈血。採用酶聯免疫法檢測兩組的血清疼痛物質（P物質、神經肽Y、神經生長因子）及炎性應激指標（白細胞介素-1β、白細胞介素-6、白細胞介素-8、白細胞介素-10、降鈣素原、超敏熱休剋蛋白、腫瘤壞死因子-α、榦擾素-γ）水平併進行比較，同時比較觀察組中不同PPI分級者的檢測水平。<br> 結果：觀察組的血清疼痛物質及炎性應激指標水平均顯著高于對照組，且觀察組中PPI分級較高者的檢測水平高于PPI分級較低者（P＜0.05）。<br> 結論：腰椎間盤突齣患者血清疼痛物質及炎性應激指標均呈高錶達狀態，且受疼痛程度的影響較大。
배경：요추간반돌출시림상교위상견적질병，다수환자유불동정도적동통표현，엄중영향생활질량。목적：탐토요추간반돌출환자혈청동통물질급염성응격지표적변화。<br> 방법：수집2012년7월지2014년5월수치적88례요추간반돌출환자（관찰조）화동기진행건강체검적88례지원자（대조조）적외주정맥혈。채용매련면역법검측량조적혈청동통물질（P물질、신경태Y、신경생장인자）급염성응격지표（백세포개소-1β、백세포개소-6、백세포개소-8、백세포개소-10、강개소원、초민열휴극단백、종류배사인자-α、간우소-γ）수평병진행비교，동시비교관찰조중불동PPI분급자적검측수평。<br> 결과：관찰조적혈청동통물질급염성응격지표수평균현저고우대조조，차관찰조중PPI분급교고자적검측수평고우PPI분급교저자（P＜0.05）。<br> 결론：요추간반돌출환자혈청동통물질급염성응격지표균정고표체상태，차수동통정도적영향교대。
Background:Lumbar disc protrusion is a common disease in clinic, and pain presents in most patients and seriously affects the quality of life. <br> Objective:To investigate the changes of serum pain substances and inflammatory stress indexes in patients with lumbar disc protrusion. <br> Methods:Peripheral vein blood was collected from 88 patients with lumbar disc protrusion treated in our hospital from July 2012 to May 2014 (observation group) and 88 healthy persons (control group). Serum pain substances (P substance, neuro-peptide Y, nerve growth factor) and inflammatory stress indexes (interleukin 1β, interleukin 6, interleukin 8, interleukin 10, procalcitonin, supersensitive heat shock protein, tumor necrosis factorα, interferonγ) were detected by euzymelinked immu-nosorbent assay and compared between groups. <br> Results:The levels of serum pain substances and inflammatory stress indexes in the observation group were all significantly higher than those in the control group (P<0.05). The higher PPI classifications were, and the higher levels of serum pain sub-stances and inflammatory stress indexes were. <br> Conclusions:The expression of serum pain substances and inflammatory stress indexes are at a high status and related to the severity of pain.
