CAJ | 학술논문

目的：研究糖尿病足溃疡患者血小板聚集、释放和膜糖蛋白Ⅵ(GPⅥ)的变化。方法42例2型糖尿病患者按有无糖尿病足分为：非糖尿病足(DM)组(未患糖尿病足)17例和糖尿病足(DFU)组25例；同时选取15例健康志愿者为对照组。检测空腹血糖值、糖化血红蛋白、血小板聚集率、血小板P选择素释放和血小板GPⅥ阳性率。结果 DFU组空腹血糖值和糖化血红蛋白(HbA1c)两项指标均高于对照组(P<0.05)；DFU组血小板聚集率显著高于对照组与DM组(P<0.05)；DFU组血小板P选择素释放高于对照组与DM组(P<0.05)；DFU组的GPⅥ阳性率高于对照组和DM组，差异均具有统计学意义(P<0.05)。结论血小板功能的变化可能与糖尿病足的发病有关。
목적：연구당뇨병족궤양환자혈소판취집、석방화막당단백Ⅵ(GPⅥ)적변화。방법42례2형당뇨병환자안유무당뇨병족분위：비당뇨병족(DM)조(미환당뇨병족)17례화당뇨병족(DFU)조25례；동시선취15례건강지원자위대조조。검측공복혈당치、당화혈홍단백、혈소판취집솔、혈소판P선택소석방화혈소판GPⅥ양성솔。결과 DFU조공복혈당치화당화혈홍단백(HbA1c)량항지표균고우대조조(P<0.05)；DFU조혈소판취집솔현저고우대조조여DM조(P<0.05)；DFU조혈소판P선택소석방고우대조조여DM조(P<0.05)；DFU조적GPⅥ양성솔고우대조조화DM조，차이균구유통계학의의(P<0.05)。결론혈소판공능적변화가능여당뇨병족적발병유관。
Objective To research platelet aggregation, release and change of membrane glycoproteinⅥin diabetic foot ulceration. Methods A total of 42 patients with type 2 diabetes mellitus were divided into non diabetic foot (DM)group (without diabetic foot) with 17 cases and diabetic foot (DFU) group with 25 cases. Another 15 healthy volunteers were selected as control group. Detection was made on fasting blood-glucose, glycosylated hemoglobin, platelet aggregation rate, platelet P-selectin release, and platelet GPⅥpositive rate. Results DFU group had higher indexes of fasting blood-glucose and glycosylated hemoglobin (HbA1c) than the control group (P<0.05). DFU group had higher platelet aggregation rate than the control group and DM group (P<0.05). DFU group had higher platelet P-selectin release than the control group and DM group (P<0.05). DFU group had higher GPⅥpositive rate than the control group and DM group, and the differences had statistical significance (P<0.05). Conclusion Change of platelet function have relationship with the progress of diabetic foot.