CAJ | 학술논문

目的：研究辛伐他汀对脓毒症并发急性呼吸窘迫综合征(ARDS)患者外周血CD4+CD2+5调节性T细胞(Treg)的影响。方法65例脓毒症患者随机分为辛伐他汀治疗组(n=32)和对照组(n=33)。采集患者入选研究后的外周血行白细胞计数(WBC), C反应蛋白(CRP),降钙素原(PCT)检测来反映患者的感染程度,同时记录急性生理和慢性健康(APACHEⅡ)评分,流式细胞术(FCM)检测各组入选时、1、3、5、7、14 d的外周血CD4+CD2+5Treg的水平。结果两组间的一般资料比较差异无统计学意义(P>0.05)。辛伐他汀治疗组的CD4+CD2+5Treg在T淋巴细胞中的百分比逐渐下降,第14天两组间比较差异具有统计学意义[(7.32±1.86)%VS (10.01±5.63)%, t=2.568, P=0.013)]。结论辛伐他汀能改善脓毒症并发ARDS患者Treg过多的现象,起到调节免疫紊乱的功能。
목적：연구신벌타정대농독증병발급성호흡군박종합정(ARDS)환자외주혈CD4+CD2+5조절성T세포(Treg)적영향。방법65례농독증환자수궤분위신벌타정치료조(n=32)화대조조(n=33)。채집환자입선연구후적외주혈행백세포계수(WBC), C반응단백(CRP),강개소원(PCT)검측래반영환자적감염정도,동시기록급성생리화만성건강(APACHEⅡ)평분,류식세포술(FCM)검측각조입선시、1、3、5、7、14 d적외주혈CD4+CD2+5Treg적수평。결과량조간적일반자료비교차이무통계학의의(P>0.05)。신벌타정치료조적CD4+CD2+5Treg재T림파세포중적백분비축점하강,제14천량조간비교차이구유통계학의의[(7.32±1.86)%VS (10.01±5.63)%, t=2.568, P=0.013)]。결론신벌타정능개선농독증병발ARDS환자Treg과다적현상,기도조절면역문란적공능。
Objective To explore the influence of simvastatin on CD4+CD25+regulatory T cell (Treg) in patients of sepsis complicated with acute respiratory distress syndrome (ARDS). Methods A total of 65 sepsis patients were randomly divided into simvastatin treatment group (n=32) and control group (n=33). Their peripheral blood white blood count (WBC), C-reactive protein (CRP) and procalcitonin (PCT) were collected and detected to show their infection degree. Their acute physiology score (APACHEⅡ) were recorded, and their peripheral blood CD4+CD25+Treg levels were detected by flowcytometry (FCM) in admission time, and 1, 3, 5, 7, 14 d. Results There was no statistically significant difference of general information between the two groups (P>0.05). The CD4+CD25+Treg levels had decreasing percentage in T lymphocyte in the simvastatin treatment group. On 14 d, the difference between the two groups had statistical significance[(7.32±1.86)%VS (10.01±5.63)%, t=2.568, P=0.013)]. Conclusion Simvastatin can improve the Treg redundance in patients of sepsis complicated with ARDS, and it has regulation function for immunologic derangement.