中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
7期
284-285
,共2页
缺氧-复氧%心肌细胞%丹参水提物
缺氧-複氧%心肌細胞%丹參水提物
결양-복양%심기세포%단삼수제물
Hypoxia-reoxygenation%Myocardial cells%Salvia miltiorrhiza aqueous extract
本文研究丹参水提物对乳鼠心肌细胞缺氧-复氧损伤的保护作用。以乳鼠心室肌进行心肌细胞培养并建立缺氧-复氧损伤模型，检测不同浓度丹参水提物预处理后细胞的存活率，乳酸脱氢酶(LDH)、肌酸激酶(CK)、天冬氨酸转移酶(AST)的泄漏量及Akt的磷酸化水平。丹参水提物对缺氧-复氧损伤的心肌细胞具有明显的保护作用，这可能与它激活PI3K/Akt信号通路有关。
本文研究丹參水提物對乳鼠心肌細胞缺氧-複氧損傷的保護作用。以乳鼠心室肌進行心肌細胞培養併建立缺氧-複氧損傷模型，檢測不同濃度丹參水提物預處理後細胞的存活率，乳痠脫氫酶(LDH)、肌痠激酶(CK)、天鼕氨痠轉移酶(AST)的洩漏量及Akt的燐痠化水平。丹參水提物對缺氧-複氧損傷的心肌細胞具有明顯的保護作用，這可能與它激活PI3K/Akt信號通路有關。
본문연구단삼수제물대유서심기세포결양-복양손상적보호작용。이유서심실기진행심기세포배양병건립결양-복양손상모형，검측불동농도단삼수제물예처리후세포적존활솔，유산탈경매(LDH)、기산격매(CK)、천동안산전이매(AST)적설루량급Akt적린산화수평。단삼수제물대결양-복양손상적심기세포구유명현적보호작용，저가능여타격활PI3K/Akt신호통로유관。
To study the protective effect by Salvia Miltiorrhiza aqueous extract for hypoxia-reoxygenation damage in myocardial cells of suckling mice. The hypoxia-reoxygenation damage model was made from myocardial cells culture of suckling mice. Detection was taken on cells survival rate, leakage rates of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate transaminase (AST), and phosphorylation level of Akt of cells in different concentrations of Salvia Miltiorrhiza aqueous extract. Salvia Miltiorrhiza aqueous extract provides obviously protective effect for myocardial cells with hypoxia-reoxygenation damage, and that may be related with its activation of PI3K/Akt signal path.
