中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
6期
10-12
,共3页
降钙素原%慢性阻塞性肺疾病%急性加重期%抗生素
降鈣素原%慢性阻塞性肺疾病%急性加重期%抗生素
강개소원%만성조새성폐질병%급성가중기%항생소
Procalcitonin%Chronic obstructive pulmonary disease%Acute exacerbation%Antibiotics
目的：探讨血清降钙素原(PCT)在慢性阻塞性肺疾病急性加重期(AECOPD)优化抗生素应用中的价值。方法80例AECOPD患者随机分为观察组和对照组，各40例，对照组根据经验使用抗生素，观察组根据血清PCT水平指导抗生素应用。当血清PCT≥0.25 ng/ml时，进行抗生素治疗，当PCT<0.25 ng/ml时，则停止使用抗生素治疗。并观察两组患者抗生素的使用疗程，抗生素所用费用及住院时间。结果观察组患者抗菌药物疗程、抗生素使用费用、住院费用及二重感染率明显低于对照组，差异有统计学意义(P<0.05)。两组的住院时间及临床有效率比较差异无统计学意义(P>0.05)。结论 AECOPD患者根据PCT水平使用抗生素，能较明显缩短抗生素的使用疗程，减少医疗费用，有效防止抗生素过度使用。
目的：探討血清降鈣素原(PCT)在慢性阻塞性肺疾病急性加重期(AECOPD)優化抗生素應用中的價值。方法80例AECOPD患者隨機分為觀察組和對照組，各40例，對照組根據經驗使用抗生素，觀察組根據血清PCT水平指導抗生素應用。噹血清PCT≥0.25 ng/ml時，進行抗生素治療，噹PCT<0.25 ng/ml時，則停止使用抗生素治療。併觀察兩組患者抗生素的使用療程，抗生素所用費用及住院時間。結果觀察組患者抗菌藥物療程、抗生素使用費用、住院費用及二重感染率明顯低于對照組，差異有統計學意義(P<0.05)。兩組的住院時間及臨床有效率比較差異無統計學意義(P>0.05)。結論 AECOPD患者根據PCT水平使用抗生素，能較明顯縮短抗生素的使用療程，減少醫療費用，有效防止抗生素過度使用。
목적：탐토혈청강개소원(PCT)재만성조새성폐질병급성가중기(AECOPD)우화항생소응용중적개치。방법80례AECOPD환자수궤분위관찰조화대조조，각40례，대조조근거경험사용항생소，관찰조근거혈청PCT수평지도항생소응용。당혈청PCT≥0.25 ng/ml시，진행항생소치료，당PCT<0.25 ng/ml시，칙정지사용항생소치료。병관찰량조환자항생소적사용료정，항생소소용비용급주원시간。결과관찰조환자항균약물료정、항생소사용비용、주원비용급이중감염솔명현저우대조조，차이유통계학의의(P<0.05)。량조적주원시간급림상유효솔비교차이무통계학의의(P>0.05)。결론 AECOPD환자근거PCT수평사용항생소，능교명현축단항생소적사용료정，감소의료비용，유효방지항생소과도사용。
Objective To explore the value of procalcitonin (PCT) for optimized antibiotics application in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 80 AECOPD patients were randomly divided into observation group and control group, with 40 cases in each group. The control group received antibiotics by application experience, while the observation group was given antibiotics under guidance of serum PCT level. When serum PCT≥0.25 ng/ml, antibiotics was given;When PCT<0.25 ng/ml, application <br> of antibiotics was stopped. Antibiotics application course, antibiotics application costs and hospital stays of the two groups were observed. Results The observation group had obviously shorter antibiotics application course, and lower antibiotics application costs and double infection rate than the control group, and the difference had statistical significance (P<0.05). There were no statistically significant differences of hospital stays and clinical effective rates between the two groups (P>0.05). Conclusion The antibiotics use under guidance by PCT level for AECOPD patients can remarkably reduce antibiotics application course and medical costs, and it can also effectively prevent overuse of antibiotics.
