中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
6期
23-24
,共2页
磷酸西格列汀%门冬胰岛素30%2型糖尿病%临床疗效
燐痠西格列汀%門鼕胰島素30%2型糖尿病%臨床療效
린산서격렬정%문동이도소30%2형당뇨병%림상료효
Sitagliptin phosphate%Insulin aspart 30%Type 2 diabetes mellitus%Clinical effect
目的:观察磷酸西格列汀联合门冬胰岛素30治疗2型糖尿病的临床疗效与安全性。方法接受门冬胰岛素30治疗的血糖控制不理想的2型糖尿病患者60例,随机分为西格列汀组和二甲双胍组,各30例。西格列汀组给予西格列汀100 mg/d口服,二甲双胍组给予二甲双胍1.0 g/d,两组根据血糖监测情况适时调整门冬胰岛素30用量,疗程12周。检测两组用药前后空腹血糖(FPG),餐后2 h血糖(2 h PG),糖化血红蛋白(HbA1c),观察不良反应。结果西格列汀组完成29例,二甲双胍组完成28例。两组患者的空腹血糖、餐后2 h血糖及糖化血红蛋白值均较治疗前明显下降,差异有统计学意义(P<0.05);治疗后两组比较,西格列汀组优于二甲双胍组(P<0.05)。均无严重不良反应。结论磷酸西格列汀联合门冬胰岛素30治疗2型糖尿病有明显疗效,可以更好控制血糖,无明显不良反应,耐受性好。
目的:觀察燐痠西格列汀聯閤門鼕胰島素30治療2型糖尿病的臨床療效與安全性。方法接受門鼕胰島素30治療的血糖控製不理想的2型糖尿病患者60例,隨機分為西格列汀組和二甲雙胍組,各30例。西格列汀組給予西格列汀100 mg/d口服,二甲雙胍組給予二甲雙胍1.0 g/d,兩組根據血糖鑑測情況適時調整門鼕胰島素30用量,療程12週。檢測兩組用藥前後空腹血糖(FPG),餐後2 h血糖(2 h PG),糖化血紅蛋白(HbA1c),觀察不良反應。結果西格列汀組完成29例,二甲雙胍組完成28例。兩組患者的空腹血糖、餐後2 h血糖及糖化血紅蛋白值均較治療前明顯下降,差異有統計學意義(P<0.05);治療後兩組比較,西格列汀組優于二甲雙胍組(P<0.05)。均無嚴重不良反應。結論燐痠西格列汀聯閤門鼕胰島素30治療2型糖尿病有明顯療效,可以更好控製血糖,無明顯不良反應,耐受性好。
목적:관찰린산서격렬정연합문동이도소30치료2형당뇨병적림상료효여안전성。방법접수문동이도소30치료적혈당공제불이상적2형당뇨병환자60례,수궤분위서격렬정조화이갑쌍고조,각30례。서격렬정조급여서격렬정100 mg/d구복,이갑쌍고조급여이갑쌍고1.0 g/d,량조근거혈당감측정황괄시조정문동이도소30용량,료정12주。검측량조용약전후공복혈당(FPG),찬후2 h혈당(2 h PG),당화혈홍단백(HbA1c),관찰불량반응。결과서격렬정조완성29례,이갑쌍고조완성28례。량조환자적공복혈당、찬후2 h혈당급당화혈홍단백치균교치료전명현하강,차이유통계학의의(P<0.05);치료후량조비교,서격렬정조우우이갑쌍고조(P<0.05)。균무엄중불량반응。결론린산서격렬정연합문동이도소30치료2형당뇨병유명현료효,가이경호공제혈당,무명현불량반응,내수성호。
Objective To observe the clinical effect and safety of sitagliptin phosphate combined with insulin aspart 30 in the treatment of type 2 diabetes mellitus. Methods There were 60 patients in our hospital’s outpatient department, who receiving insulin aspart 30 for treatment without reaching standard level of blood glucose. They were randomly divided into sitagliptin group and metformin group, and each group contained 30 cases. The sitagliptin group received oral administration of sitagliptin for 100 mg/d, and the metformin group was given metformin for 1.0 g/d. Adjustment of insulin was made according to their blood glucose monitoring conditions. The treatment lasted for 12 weeks. Fasting plasma glucose (FPG), 2 h postprandial blood glucose (2hPG), and glycosylated hemoglobin (HbA1c) were detected in the two groups before and after treatment. Adverse reactions were observed. Results There were 29 completed cases in the sitagliptin group, and 28 completed cases in the metformin group. Both groups had obviously lower levels of fasting blood glucose, 2 h postprandial blood glucose, and glycosylated hemoglobin after treatment than those before treatment. The difference had statistical significance (P<0.05). After treatment, the sitagliptin group was better than the metformin group (P<0.05). No severe adverse reactions were found in the two groups. Conclusion Sitagliptin phosphate combined with insulin aspart 30 has precise effect in the treatment of type 2 diabetes mellitus. It can control blood glucose effectively with good tolerance and no obviously adverse reactions.