CAJ | 학술논문

目的：探讨新生儿高胆红素血症的相关影响因素，为临床预防及治疗新生儿高胆红素血症治疗提供理论依据。方法对2011年1月—2012年1月新疆医科大学第一附属医院5023例新生儿（产科新生儿4442例及新生儿科高胆红素血症病例581例）临床资料进行回顾性及描述性分析，采用 Logistic 回归分析其影响因素。结果（1）单因素分析显示：民族、胎龄、出生体质量、胎膜早破、头颅血肿、喂养方式、缺氧、产前抗生素应用、母子血型不合、开奶时间、胎便排出时间、同胞中有高胆红素血症12项为影响因素。（2）Logistic 回归分析显示：缺氧、产前抗生素使用、胎便排出时间差异无统计学意义（P ＞0．05）；民族、胎龄、出生体质量为新生儿高胆红素血症保护性因素；胎膜早破、头颅血肿、喂养方式、母子血型不合、开奶时间、同胞中有高胆红素血症为新生儿高胆红素血症危险因素（P ＜0．05）。（3）多元 Logistic 回归分析显示：胎龄和出生体质量为新生儿高胆红素血症保护性因素（P ＜0．05），母子血型不合、开奶时间、同胞中高胆红素血症、胎膜早破为其病情严重程度的危险因素（P ＜0．05）。结论新生儿高胆红素血症与多种相关因素有关，应根据相关危险因素制定诊治方案，积极预防感染，重视产前相关检查及产后胆红素监测，降低高胆红素血症发病率，减少高胆红素血症对新生儿生长发育的影响。
목적：탐토신생인고담홍소혈증적상관영향인소，위림상예방급치료신생인고담홍소혈증치료제공이론의거。방법대2011년1월—2012년1월신강의과대학제일부속의원5023례신생인（산과신생인4442례급신생인과고담홍소혈증병례581례）림상자료진행회고성급묘술성분석，채용 Logistic 회귀분석기영향인소。결과（1）단인소분석현시：민족、태령、출생체질량、태막조파、두로혈종、위양방식、결양、산전항생소응용、모자혈형불합、개내시간、태편배출시간、동포중유고담홍소혈증12항위영향인소。（2）Logistic 회귀분석현시：결양、산전항생소사용、태편배출시간차이무통계학의의（P ＞0．05）；민족、태령、출생체질량위신생인고담홍소혈증보호성인소；태막조파、두로혈종、위양방식、모자혈형불합、개내시간、동포중유고담홍소혈증위신생인고담홍소혈증위험인소（P ＜0．05）。（3）다원 Logistic 회귀분석현시：태령화출생체질량위신생인고담홍소혈증보호성인소（P ＜0．05），모자혈형불합、개내시간、동포중고담홍소혈증、태막조파위기병정엄중정도적위험인소（P ＜0．05）。결론신생인고담홍소혈증여다충상관인소유관，응근거상관위험인소제정진치방안，적겁예방감염，중시산전상관검사급산후담홍소감측，강저고담홍소혈증발병솔，감소고담홍소혈증대신생인생장발육적영향。
Objective The study is to investigate the related factors in neonatal hyperbilirubinemia,and to provide clinical evidence for clinical prevention and treatment of neonatal hyperbilirubinemia.Methods 5 023 cases neonatal (normal newborn of 4442 cases and 581 cases of hyperbilirubinemia )from Depart-ment of Obstetrics and neonatology in The First Affiliated Hospital of Xinjiang Medical University from January 2011 to January 2012 were retrospectively reviewed and the related factors were analyzed by using Logistic regression.Results (1 )Single factor analysis of the related factors showed that the related factors included ethnicity,gestational age,birth weight,premature rupture of membranes,cephalhemato-ma,way of feeding,hypoxia,antibiotics,prenatal mother and child blood group incompatibility,open milk time,meconium discharge time,compatriots in neonatal hyperbilirubinemia.(2)Logistic regression analysis of the related factors showed that ethnicity,gestational age,birth weight are the protective factors (P <0.05),while premature rupture of membranes,cephalhematoma,method of feeding,mother and child blood group incompatibility,open milk time,compatriots in neonatal hyperbilirubinemia are the risk factors (P <0.05).(3)Multivariate logistic analysis showed that gestational age and birth weight are protective factors in the neonatal hyperbilirubinemia (P <0.05),while mother and child blood group in-compatibility,open milk time,hyperbilirubinemia compatriots and premature rupture of membranes are the risk factors (P <0.05).Conclusion There are a variety of related factors in neonatal hyperbilirubi-nemia.We should decide proper treatments with regard to the related risk factors and prevent infection, put emphasis on prenatal inspection and after-birth bilirubin monitoring in order to reduce the incidence of hyperbilirubinemia,particularly the incidence of severe of hyperbilirubinemia,and the impact of hyperbil-irubinemia on neonatal growth and development.