CAJ | 학술논문

目的：探讨中西医结合卒中单元模式对新疆地区维吾尔族（维族）、汉族急性脑梗死患者血清内皮素1（ET-1）、血栓素 B2（TXB2）的影响及临床疗效。方法选择在新疆医科大学附属中医医院住院的维族、汉族急性脑梗死患者400例，随机分为维、汉族对照组和治疗组，每组各100例，取得患者及其家属同意后，治疗组接受中西医结合卒中单元模式治疗，对照组接受常规卒中单元模式治疗。2 w 后，比较维、汉族急性脑梗死患者治疗前后卒中量表（NIHSS）评分及血清 ET-1、TXB2水平。结果维、汉族急性脑梗死患者治疗组和对照组治疗前后NIHSS 评分差异均有统计学意义（P ＜0．01），维、汉族治疗组与对照组治疗前后 NIHSS 评分均有统计学意义（P＜0．05），维族治疗组与汉族治疗组治疗前后 NIHSS 评分差比较差异有统计学意义（P ＜0．05）；维、汉族治疗组和对照组治疗前后 ET-1含量比较差异有统计学意义（P ＜0．01），维、汉族治疗组与对照组治疗前后 ET-1含量差比较差异有统计学意义（P ＜0．01），维族治疗组与汉族治疗组治疗前后 ET-1含量差比较差异无统计学意义（P ＞0．05）；维、汉族治疗组治疗前后 TXB2含量比较差异均有统计学意义（P ＜0．01），维、汉族对照组治疗前后 TXB2含量比较差异均有统计学意义（P ＜0．05），维、汉族治疗组与对照组治疗前后 TXB2含量差比较差异无统计学意义（P ＞0．05），维、汉族治疗组治疗前后 TXB2含量差比较差异无统计学意义（P ＞0．05）。结论中西医结合卒中单元模式治疗维族、汉族急性脑梗死患者均有较好疗效，维、汉族患者 ET-1、TXB2均改善明显，尤其是对维族患者临床疗效更佳。
목적：탐토중서의결합졸중단원모식대신강지구유오이족（유족）、한족급성뇌경사환자혈청내피소1（ET-1）、혈전소 B2（TXB2）적영향급림상료효。방법선택재신강의과대학부속중의의원주원적유족、한족급성뇌경사환자400례，수궤분위유、한족대조조화치료조，매조각100례，취득환자급기가속동의후，치료조접수중서의결합졸중단원모식치료，대조조접수상규졸중단원모식치료。2 w 후，비교유、한족급성뇌경사환자치료전후졸중량표（NIHSS）평분급혈청 ET-1、TXB2수평。결과유、한족급성뇌경사환자치료조화대조조치료전후NIHSS 평분차이균유통계학의의（P ＜0．01），유、한족치료조여대조조치료전후 NIHSS 평분균유통계학의의（P＜0．05），유족치료조여한족치료조치료전후 NIHSS 평분차비교차이유통계학의의（P ＜0．05）；유、한족치료조화대조조치료전후 ET-1함량비교차이유통계학의의（P ＜0．01），유、한족치료조여대조조치료전후 ET-1함량차비교차이유통계학의의（P ＜0．01），유족치료조여한족치료조치료전후 ET-1함량차비교차이무통계학의의（P ＞0．05）；유、한족치료조치료전후 TXB2함량비교차이균유통계학의의（P ＜0．01），유、한족대조조치료전후 TXB2함량비교차이균유통계학의의（P ＜0．05），유、한족치료조여대조조치료전후 TXB2함량차비교차이무통계학의의（P ＞0．05），유、한족치료조치료전후 TXB2함량차비교차이무통계학의의（P ＞0．05）。결론중서의결합졸중단원모식치료유족、한족급성뇌경사환자균유교호료효，유、한족환자 ET-1、TXB2균개선명현，우기시대유족환자림상료효경가。
Objective To observe the effects and clinical significance of integrative treatment model on ET-1 and TXB2 of serum in Uyghur and Han patients with acute cerebral infarction in Xinjiang.Methods 400 cases of Han and Uyghur patients with acute cerebral infarction were selected and grouped:200 Han pa-tients were randomly divided into treatment group and control group,with 100 cases in each group;200 Uyghur patients were randomly divided into treatment group and control group,with 100 cases in each group.The integrative treatment model was applied in the treatment group and the conventional treatment was applied in the control group.National Institutes of Health Stroke Scale (NIHSS)score,clinical effica-cy and serum ET-1,TXB2 content changes in the pre-treatment and post-treatment in 2 weeks were com-pared and analyzed.Results Two peoples with acute cerebral infarction in treatment group and the control group in pre-treatment and post-treatment had significant difference in NIHSS scores (P <0.01);NIHSS scores in Uyghur treatment group and the control group in pre-treatment and post-treatment differed sig-nificantly (P <0.01);Han treatment group and the control group in pre-treatment and post-treatment had NIHSS score difference (P <0.05);Uyghur and Han treatment group in pre-treatment and post-treatment had NIHSS score difference (P <0.05);ET1 content and ET-1 levels in two treatment and control groups in pre-treatment and post-treatment differed significantly (P <0.01),with no significant difference (P >0.05)in Uyghur and Han treatment group in pre-treatment and post-treatment;TXB2 content in two peo-ples had significant difference (P <0.01);TXB2 levels in Uyghur control group and in Han groups had significant differences (P <0.01).Conclusion It proved that the integrative treatment model for Han pa-tients and Uyghur patients with acute cerebral infarction was effective,with obvious improvement in serum ET-1 and TXB2 level,especially for Uyghur patients.